2-[3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-phenylselanyl-propionitrile

Base Information

Chemical Name:2-[3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-phenylselanyl-propionitrile
CAS No.:405082-22-6
Molecular Formula:C₂₄H₃₃N₃O₄SeSi
Molecular Weight:534.589
Hs Code.:

2-[3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-phenylselanyl-propionitrile

Synonyms:2-[3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-phenylselanyl-propionitrile

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Chemical Property of 2-[3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-phenylselanyl-propionitrile

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Technology Process of 2-[3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-phenylselanyl-propionitrile

There total 3 articles about 2-[3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-phenylselanyl-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 645-96-5
Benzeneselenol

: 405082-20-4
1-[3-O-(tert-butyldimethylsilyl)-2,5-dideoxy-5-C-methylene-β-D-erythro-hexofuranosylurononitrile]thymine

: 405082-22-6
2-[3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-phenylselanyl-propionitrile

Guidance literature:: With triethylamine; at 20 ℃; for 1h;
DOI:10.1081/NCN-100108323

Reference yield:

: 405082-19-1
1-[(E)-3-O-(tert-butyldimethylsilyl)-2,5,6-trideoxy-6-nitro-β-D-erythro-hex-5-enofuranosyl]thymine

: 405082-22-6
2-[3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-phenylselanyl-propionitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / NaOAcn-Bu₄NHSO₄ / acetic acid; H₂O / pH 6.0 - 7.0

2: 79 percent / Et₃N / 1 h / 20 °C

With sodium acetate; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; In water; acetic acid;
DOI:10.1081/NCN-100108323

Reference yield:

: 1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(1-hydroxy-2-nitro-ethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 405082-22-6
2-[3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-phenylselanyl-propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / sodium acetate; acetic anhydride / 8 h / 0 - 20 °C

2: 85 percent / NaOAcn-Bu₄NHSO₄ / acetic acid; H₂O / pH 6.0 - 7.0

3: 79 percent / Et₃N / 1 h / 20 °C

With sodium acetate; tetra(n-butyl)ammonium hydrogensulfate; acetic anhydride; triethylamine; In water; acetic acid;
DOI:10.1081/NCN-100108323