N-[2-(2,5-dichloropyrimidin-4-ylamino)-4-vinylphenyl]-N-methylmethanesulfonamide

Base Information

Chemical Name:N-[2-(2,5-dichloropyrimidin-4-ylamino)-4-vinylphenyl]-N-methylmethanesulfonamide
CAS No.:1352244-22-4
Molecular Formula:C₁₄H₁₄Cl₂N₄O₂S
Molecular Weight:373.263
Hs Code.:

Synonyms:N-[2-(2,5-dichloropyrimidin-4-ylamino)-4-vinylphenyl]-N-methylmethanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-(2,5-dichloropyrimidin-4-ylamino)-4-vinylphenyl]-N-methylmethanesulfonamide

Chemical Property:

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Technology Process of N-[2-(2,5-dichloropyrimidin-4-ylamino)-4-vinylphenyl]-N-methylmethanesulfonamide

There total 5 articles about N-[2-(2,5-dichloropyrimidin-4-ylamino)-4-vinylphenyl]-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1352244-14-4
N-(2-amino-4-vinylphenyl)-N-methylmethanesulfonamide

: 5750-76-5
2,4,5-trichloropyrimidine

: 1352244-22-4
N-[2-(2,5-dichloropyrimidin-4-ylamino)-4-vinylphenyl]-N-methylmethanesulfonamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 120 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm201333e

Reference yield:

: 1352244-85-9
N-(4-bromo-2-nitrophenyl)methanesulfonamide

: 1352244-22-4
N-[2-(2,5-dichloropyrimidin-4-ylamino)-4-vinylphenyl]-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 16 h / 90 °C / Inert atmosphere

3: iron; acetic acid / tetrahydrofuran / 16 h / 35 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 120 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm201333e

Reference yield:

: 1078136-96-5
N-(4-bromo-2-nitrophenyl)-N-methylmethanesulfonamide

: 1352244-22-4
N-[2-(2,5-dichloropyrimidin-4-ylamino)-4-vinylphenyl]-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 16 h / 90 °C / Inert atmosphere

2: iron; acetic acid / tetrahydrofuran / 16 h / 35 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 120 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iron; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm201333e