phenoxy-acetic acid 4-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-butyl ester

Base Information

Chemical Name:phenoxy-acetic acid 4-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-butyl ester
CAS No.:749254-12-4
Molecular Formula:C₄₉H₆₀N₂O₁₀Si
Molecular Weight:865.108
Hs Code.:

phenoxy-acetic acid 4-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2<i>H</i>-pyrimidin-1-yl}-butyl ester

Synonyms:phenoxy-acetic acid 4-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-butyl ester

Suppliers and Price of phenoxy-acetic acid 4-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of phenoxy-acetic acid 4-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of phenoxy-acetic acid 4-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-butyl ester

There total 1 articles about phenoxy-acetic acid 4-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.2%

: 80971-33-1
5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine

: 4-iodobutyl phenoxyacetate

: 749254-12-4
phenoxy-acetic acid 4-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-butyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;
DOI:10.1021/ja0498540

Reference yield:

: 749254-12-4
phenoxy-acetic acid 4-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-butyl ester

: 1-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3-(4-hydroxy-butyl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With propylamine; In dichloromethane;
DOI:10.1021/ja0498540

Reference yield:

: 749254-12-4
phenoxy-acetic acid 4-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-butyl ester

: 749254-18-0
N₃-(4-iodobutyl)-5'-O-(4,4'-dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-thymidine

Guidance literature:: Multi-step reaction with 2 steps

1: propylamine / CH₂Cl₂

2: imidazole; PPh₃; I₂ / tetrahydrofuran / 0 °C

With 1H-imidazole; propylamine; iodine; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja0498540