7-[(S)-2-(1-Ethoxy-ethoxymethyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid methyl ester

Base Information

Chemical Name:7-[(S)-2-(1-Ethoxy-ethoxymethyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid methyl ester
CAS No.:67087-17-6
Molecular Formula:C₁₇H₃₁NO₅
Molecular Weight:329.437
Hs Code.:

Synonyms:7-[(S)-2-(1-Ethoxy-ethoxymethyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid methyl ester

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Chemical Property of 7-[(S)-2-(1-Ethoxy-ethoxymethyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid methyl ester

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Technology Process of 7-[(S)-2-(1-Ethoxy-ethoxymethyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid methyl ester

There total 1 articles about 7-[(S)-2-(1-Ethoxy-ethoxymethyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 67087-17-6
7-[(S)-2-(1-Ethoxy-ethoxymethyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / trichloroacetic acid / CHCl₃ / 4 h / Ambient temperature

2: 25.5 g / 65percent NaH, KI / dimethylformamide

With sodium hydride; potassium iodide; trichloroacetic acid; In chloroform; N,N-dimethyl-formamide;

Reference yield:

: 67087-17-6
methyl 7-((2R)-2-((1-ethoxyethoxy)methyl)-5-oxopyrrolidin-1-yl)heptanoate

: (R,E)-methyl 7-(2-oxo-5-(3-oxo-7-phenylhept-1-en-1-yl)pyrrolidin-1-yl)heptanoate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / methanol / 18 h / 20 °C

2: Dess-Martin periodane / dichloromethane / 20 °C

3: triethylamine; lithium chloride / tetrahydrofuran / 0 - 20 °C

With Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; lithium chloride; In tetrahydrofuran; methanol; dichloromethane; 3: |Horner-Wadsworth-Emmons Olefination;

Reference yield:

: 67087-17-6
methyl 7-((2R)-2-((1-ethoxyethoxy)methyl)-5-oxopyrrolidin-1-yl)heptanoate

: 7-((R)-2-((S,E)-3-hydroxy-7-phenylhept-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / methanol / 18 h / 20 °C

2.1: Dess-Martin periodane / dichloromethane / 20 °C

3.1: triethylamine; lithium chloride / tetrahydrofuran / 0 - 20 °C

4.1: cerium(III) chloride heptahydrate / methanol / 1 h / -78 - -40 °C

4.2: 2 h

4.3: Resolution of racemate

5.1: sodium hydroxide; methanol / 3 h / 20 °C

With methanol; cerium(III) chloride heptahydrate; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; lithium chloride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 3.1: |Horner-Wadsworth-Emmons Olefination;