8-(2-Fluoro-benzyl)-5-methyl-2-phenyl-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine

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Chemical Name:8-(2-Fluoro-benzyl)-5-methyl-2-phenyl-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine
CAS No.:74258-21-2
Molecular Formula:C₂₁H₁₈FN₅
Molecular Weight:359.406
Hs Code.:

Synonyms:8-(2-Fluoro-benzyl)-5-methyl-2-phenyl-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine

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Chemical Property of 8-(2-Fluoro-benzyl)-5-methyl-2-phenyl-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine

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Technology Process of 8-(2-Fluoro-benzyl)-5-methyl-2-phenyl-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine

There total 5 articles about 8-(2-Fluoro-benzyl)-5-methyl-2-phenyl-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 89-99-6
2-fluorobenzylamine

: 74258-67-6
7-Chloro-6-(2-chloro-ethyl)-5-methyl-2-phenyl-[1,2,4]triazolo[1,5-a]pyrimidine

: 74258-21-2
8-(2-Fluoro-benzyl)-5-methyl-2-phenyl-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine

Guidance literature:: With sodium carbonate; In ethanol; for 2h; Heating;
DOI:10.1021/jm00182a021

Reference yield:

: 517-23-7,594837-91-9,98634-97-0,313643-49-1
3-acetyl-2-oxo-4,5-dihydrofuran

: 74258-21-2
8-(2-Fluoro-benzyl)-5-methyl-2-phenyl-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / BF₃*MeOH / ethanol / 72 h / Ambient temperature

2: 88 percent / Et₃N / H₂O / 18 h / Ambient temperature

3: 83 percent / POCl₃ / 3 h / Heating

4: 48 percent / Na₂CO₃ / ethanol / 2 h / Heating

With boron trifluoride methanol complex; sodium carbonate; triethylamine; trichlorophosphate; In ethanol; water;
DOI:10.1021/jm00182a021

Reference yield:

: 4922-98-9
3-phenyl-1H-1,2,4-triazol-5-amine

: 74258-21-2
8-(2-Fluoro-benzyl)-5-methyl-2-phenyl-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / BF₃*MeOH / ethanol / 72 h / Ambient temperature

2: 88 percent / Et₃N / H₂O / 18 h / Ambient temperature

3: 83 percent / POCl₃ / 3 h / Heating

4: 48 percent / Na₂CO₃ / ethanol / 2 h / Heating

With boron trifluoride methanol complex; sodium carbonate; triethylamine; trichlorophosphate; In ethanol; water;
DOI:10.1021/jm00182a021