3-{2-(3-Chloro-4-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]furan-3-yl}-5-fluorobenzenecarbonitrile

Base Information

Chemical Name:3-{2-(3-Chloro-4-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]furan-3-yl}-5-fluorobenzenecarbonitrile
CAS No.:1231208-88-0
Molecular Formula:C₂₁H₁₂ClF₂N₃O₃
Molecular Weight:427.794
Hs Code.:

Synonyms:3-{2-(3-Chloro-4-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]furan-3-yl}-5-fluorobenzenecarbonitrile

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Chemical Property of 3-{2-(3-Chloro-4-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]furan-3-yl}-5-fluorobenzenecarbonitrile

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Technology Process of 3-{2-(3-Chloro-4-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]furan-3-yl}-5-fluorobenzenecarbonitrile

There total 3 articles about 3-{2-(3-Chloro-4-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]furan-3-yl}-5-fluorobenzenecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187919-27-2
imidazolidin-4-one trifluoroacetate

: 1231209-20-3
C₁₈H₈ClF₂NO₃

: 1231208-88-0
3-{2-(3-Chloro-4-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]furan-3-yl}-5-fluorobenzenecarbonitrile

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 179898-34-1
3-bromo-5-fluorobenzonitrile

: 1231208-88-0
3-{2-(3-Chloro-4-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]furan-3-yl}-5-fluorobenzenecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; dimethyl sulfoxide / 90 °C / Inert atmosphere

2: caesium carbonate; XPhos / palladium diacetate / 1,2-dimethoxyethane / 48 h / 50 °C / Inert atmosphere

3: water; lithium hydroxide / tetrahydrofuran / 20 °C

4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; potassium acetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; XPhos; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dimethyl sulfoxide; 1: Suzuki Coupling;

Reference yield:

: 935685-88-4
3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenecarbonitrile

: 1231208-88-0
3-{2-(3-Chloro-4-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]furan-3-yl}-5-fluorobenzenecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; XPhos / palladium diacetate / 1,2-dimethoxyethane / 48 h / 50 °C / Inert atmosphere

2: water; lithium hydroxide / tetrahydrofuran / 20 °C

3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; XPhos; palladium diacetate; In tetrahydrofuran; 1,2-dimethoxyethane;