(rac)-4-[4-cyano-2-(methylsulfonyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid, allyl ester

Base Information

Chemical Name:(rac)-4-[4-cyano-2-(methylsulfonyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid, allyl ester
CAS No.:1161921-52-3
Molecular Formula:C₂₄H₂₀F₃N₃O₅S
Molecular Weight:519.501
Hs Code.:

(rac)-4-[4-cyano-2-(methylsulfonyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid, allyl ester

Synonyms:(rac)-4-[4-cyano-2-(methylsulfonyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid, allyl ester

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Chemical Property of (rac)-4-[4-cyano-2-(methylsulfonyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid, allyl ester

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Technology Process of (rac)-4-[4-cyano-2-(methylsulfonyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid, allyl ester

There total 10 articles about (rac)-4-[4-cyano-2-(methylsulfonyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid, allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1118-84-9
allyl acetoacetate

: 1161921-93-2
4-formyl-3-(methylsulfonyl)benzonitrile

: 13114-87-9
N-(3-trifluoromethylphenyl)urea

: 1161921-52-3
(rac)-4-[4-cyano-2-(methylsulfonyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid, allyl ester

Guidance literature:: With triethyl phosphate; phosphorus pentoxide; In tetrahydrofuran; at 60 - 80 ℃; for 4.33333h;

Reference yield: 64.0%

: 1118-84-9
allyl acetoacetate

: 1161921-97-6
4‐formyl‐3‐(methylthio)benzonitrile

: 13114-87-9
N-(3-trifluoromethylphenyl)urea

: 1161921-52-3
(rac)-4-[4-cyano-2-(methylsulfonyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid, allyl ester

Guidance literature:: With triethyl phosphate; phosphorus pentoxide; In tert-butyl methyl ether; at 50 ℃; Inert atmosphere; Reflux;

Reference yield:

: 105942-10-7
3-fluoro-4-formylbenzonitrile

: 1161921-52-3
(rac)-4-[4-cyano-2-(methylsulfonyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid, allyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dimethyl sulfoxide / Cooling with ice

2: phosphorus pentoxide; triethyl phosphate / tert-butyl methyl ether / 50 °C / Inert atmosphere; Reflux

With triethyl phosphate; phosphorus pentoxide; In tert-butyl methyl ether; dimethyl sulfoxide;