tert-butyl 3-((2S,3S)-5-(tert-butoxy)-3-(2-((4-methoxybenzyl)oxy)ethyl)-1-nitro-4,5-dioxopentan-2-yl)-6-methoxypicolinate

Base Information

Chemical Name:tert-butyl 3-((2S,3S)-5-(tert-butoxy)-3-(2-((4-methoxybenzyl)oxy)ethyl)-1-nitro-4,5-dioxopentan-2-yl)-6-methoxypicolinate
CAS No.:1585241-75-3
Molecular Formula:C₃₀H₄₀N₂O₁₀
Molecular Weight:588.655
Hs Code.:

Synonyms:tert-butyl 3-((2S,3S)-5-(tert-butoxy)-3-(2-((4-methoxybenzyl)oxy)ethyl)-1-nitro-4,5-dioxopentan-2-yl)-6-methoxypicolinate

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Chemical Property of tert-butyl 3-((2S,3S)-5-(tert-butoxy)-3-(2-((4-methoxybenzyl)oxy)ethyl)-1-nitro-4,5-dioxopentan-2-yl)-6-methoxypicolinate

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Technology Process of tert-butyl 3-((2S,3S)-5-(tert-butoxy)-3-(2-((4-methoxybenzyl)oxy)ethyl)-1-nitro-4,5-dioxopentan-2-yl)-6-methoxypicolinate

There total 28 articles about tert-butyl 3-((2S,3S)-5-(tert-butoxy)-3-(2-((4-methoxybenzyl)oxy)ethyl)-1-nitro-4,5-dioxopentan-2-yl)-6-methoxypicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1585241-67-3
(E)-tert-butyl 6-methoxy-3-(2-nitrovinyl)picolinate

: 1585241-74-2
tert-butyl 5-((4-methoxybenzyl)oxy)-2-oxopentanoate

: 1585241-75-3
tert-butyl 3-((2S,3S)-5-(tert-butoxy)-3-(2-((4-methoxybenzyl)oxy)ethyl)-1-nitro-4,5-dioxopentan-2-yl)-6-methoxypicolinate

Guidance literature:: With Ni(OAc)2-(H₂O)4-(S,S)-N,N'-dibenzylcyclohexane-1,2-diamine complex; triethylamine; In isopropyl alcohol; at -10 ℃; for 14h; stereoselective reaction;
DOI:10.1021/ol500529w

Reference yield:

: 1585241-67-3
(E)-tert-butyl 6-methoxy-3-(2-nitrovinyl)picolinate

: 1585241-74-2
tert-butyl 5-((4-methoxybenzyl)oxy)-2-oxopentanoate

: 1585241-75-3
tert-butyl 3-((2S,3S)-5-(tert-butoxy)-3-(2-((4-methoxybenzyl)oxy)ethyl)-1-nitro-4,5-dioxopentan-2-yl)-6-methoxypicolinate

: tert-butyl 3-(5-(tert-butoxy)-3-(2-((4-methoxybenzyl)oxy)ethyl)-1-nitro-4,5-dioxopentan-2-yl)-6-methoxypicolinate

Guidance literature:: With Ni(OAc)2-(H₂O)4-(S,S)-N,N'-dibenzylcyclohexane-1,2-diamine complex; In isopropyl alcohol; at 0 ℃;
DOI:10.1021/ol500529w

Reference yield:

: C₁₀H₁₃NO₅

: 1585241-75-3
tert-butyl 3-((2S,3S)-5-(tert-butoxy)-3-(2-((4-methoxybenzyl)oxy)ethyl)-1-nitro-4,5-dioxopentan-2-yl)-6-methoxypicolinate

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium chloride / dichloromethane / 15 h / 20 °C

2: water; hydrogenchloride / 1.5 h

3: triethylamine / 20 h / 20 °C

4: triethylamine; methanesulfonyl chloride / dichloromethane / 3 h / 0 °C

5: Ni(OAc)2-(H₂O)4-(S,S)-N,N'-dibenzylcyclohexane-1,2-diamine complex; triethylamine / isopropyl alcohol / 14 h / -10 °C

With hydrogenchloride; Ni(OAc)2-(H₂O)4-(S,S)-N,N'-dibenzylcyclohexane-1,2-diamine complex; water; ammonium chloride; methanesulfonyl chloride; triethylamine; In dichloromethane; isopropyl alcohol; 3: |Henry Nitro Aldol Condensation;
DOI:10.1021/ol500529w