cyclo

Base Information

Chemical Name:cyclo
CAS No.:225781-05-5
Molecular Formula:C₄₇H₇₁N₇O₁₂
Molecular Weight:926.12
Hs Code.:

cyclo<Adda-D-iso-Glu(OMe)-N-(Me)-Gly-D-Ala-L-Leu-D-β-Me-iso-Asp(OMe)-L-Ala>

Synonyms:cyclo

Suppliers and Price of cyclo

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cyclo

Chemical Property:

Purity/Quality:

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Technology Process of cyclo

There total 3 articles about cyclo which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 225781-02-2
Boc-Adda-D-iso-Glu(OMe)-N-(Me)-Gly-D-Ala-L-Leu-D-β-Me-iso-Asp(OMe)-L-Ala-OH

: 225781-05-5
cyclo

Guidance literature:: With phosphate buffer; 2,3,4,5,6-pentafluorophenol; dicyclohexyl-carbodiimide; trifluoroacetic acid; Yield given; Multistep reaction; 1.) EtOAc, 0 deg C, 1.5 h; room temperature, 6.5 h, 2.) 20 min, 3.) pH 9.5, 30 min;
DOI:10.1016/S0968-0896(98)00254-5

Reference yield:

: 134440-92-9
(2S,3S,4E,6E,8S,9S)-3-(tert-butoxycarbonyl)amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoic acid

: 225781-05-5
cyclo

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) HOAt, DCC, 2.) TFA, 3.) collidine / 1.) DMF, CH₂Cl₂, 0 deg C, 2 h; room temperature, 7 h, 2.) 1.5 h, 3.) DMF, 0 deg C, 2 h; room temperature, 12 h

2: 1.) pentafluorophenol, DCC, 2.) TFA, 3.) phosphate buffer / 1.) EtOAc, 0 deg C, 1.5 h; room temperature, 6.5 h, 2.) 20 min, 3.) pH 9.5, 30 min

With 2,3,5-trimethyl-pyridine; 1-hydroxy-7-aza-benzotriazole; phosphate buffer; 2,3,4,5,6-pentafluorophenol; dicyclohexyl-carbodiimide; trifluoroacetic acid;
DOI:10.1016/S0968-0896(98)00254-5

Reference yield:

: 225780-99-4
Boc-D-iso-Glu(OMe)-N-(Me)-Gly-D-Ala-L-Leu-D-β-Me-iso-Asp(OMe)-L-Ala-OtBu

: 225781-05-5
cyclo

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) HOAt, DCC, 2.) TFA, 3.) collidine / 1.) DMF, CH₂Cl₂, 0 deg C, 2 h; room temperature, 7 h, 2.) 1.5 h, 3.) DMF, 0 deg C, 2 h; room temperature, 12 h

2: 1.) pentafluorophenol, DCC, 2.) TFA, 3.) phosphate buffer / 1.) EtOAc, 0 deg C, 1.5 h; room temperature, 6.5 h, 2.) 20 min, 3.) pH 9.5, 30 min

With 2,3,5-trimethyl-pyridine; 1-hydroxy-7-aza-benzotriazole; phosphate buffer; 2,3,4,5,6-pentafluorophenol; dicyclohexyl-carbodiimide; trifluoroacetic acid;
DOI:10.1016/S0968-0896(98)00254-5