1-{2-[(E)-2-(ethyloxycarbonyl)ethenyl](p-methoxyphenyl)}-1H-pyrazole

Base Information

• Chemical Name: 1-{2-[(E)-2-(ethyloxycarbonyl)ethenyl](p-methoxyphenyl)}-1H-pyrazole
• CAS No.: 1350896-21-7
• Molecular Formula: C₁₅H₁₆N₂O₃
• Molecular Weight: 272.304
• Mol file: 1350896-21-7.mol

Synonyms:1-{2-[(E)-2-(ethyloxycarbonyl)ethenyl](p-methoxyphenyl)}-1H-pyrazole

Chemical Property of 1-{2-[(E)-2-(ethyloxycarbonyl)ethenyl](p-methoxyphenyl)}-1H-pyrazole

Chemical Property:

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Technology Process of 1-{2-[(E)-2-(ethyloxycarbonyl)ethenyl](p-methoxyphenyl)}-1H-pyrazole

There total 2 articles about 1-{2-[(E)-2-(ethyloxycarbonyl)ethenyl](p-methoxyphenyl)}-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1-(4-methoxyphenyl)-1H-pyrazole (35715-67-4) + ethyl acrylate (140-88-5,9003-32-1) → 1-{2-[(E)-2-(ethyloxycarbonyl)ethenyl](p-methoxyphenyl)}-1H-pyrazole (1350896-21-7)

Guidance literature:

With C₁₀H₁₄*C₁₀H₁₁O₂^(1-)*Ru⁽²⁺⁾*C₁₀H₆Br₂N₂; copper(II) acetate monohydrate; In ethanol; at 120 ℃; for 8h; Reagent/catalyst; chemoselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1007/s12039-018-1478-4

Reference yield: 32.0%

1-(4-methoxyphenyl)-1H-pyrazole (35715-67-4) + ethyl acrylate (140-88-5,9003-32-1) → 1-{2-[(E)-2-(ethyloxycarbonyl)ethenyl](p-methoxyphenyl)}-1H-pyrazole (1350896-21-7) + 1-{2,6-bis[(E)-2-(ethyloxycarbonyl)ethenyl](p-methoxyphenyl)}-1H-pyrazole (1350896-22-8)

Guidance literature:

With (p-cymene)ruthenium diacetate; copper diacetate; acetic acid; at 100 ℃; for 48h;

DOI:10.1039/c1gc15875a

upstream raw materials:

1-(4-methoxyphenyl)-1H-pyrazole

ethyl acrylate