5-(2-Morpholin-4-yl-ethoxy)-benzofuran-2-carboxylic acid ((S)-3-methyl-1-{(R)-3-oxo-1-[2-(3-pyridin-2-yl-phenyl)-acetyl]-azepan-4-ylcarbamoyl}-butyl)-amide

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Chemical Name:5-(2-Morpholin-4-yl-ethoxy)-benzofuran-2-carboxylic acid ((S)-3-methyl-1-{(R)-3-oxo-1-[2-(3-pyridin-2-yl-phenyl)-acetyl]-azepan-4-ylcarbamoyl}-butyl)-amide
CAS No.:281214-55-9
Molecular Formula:C₄₀H₄₇N₅O₇
Molecular Weight:709.842
Hs Code.:

Synonyms:5-(2-Morpholin-4-yl-ethoxy)-benzofuran-2-carboxylic acid ((S)-3-methyl-1-{(R)-3-oxo-1-[2-(3-pyridin-2-yl-phenyl)-acetyl]-azepan-4-ylcarbamoyl}-butyl)-amide

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Chemical Property of 5-(2-Morpholin-4-yl-ethoxy)-benzofuran-2-carboxylic acid ((S)-3-methyl-1-{(R)-3-oxo-1-[2-(3-pyridin-2-yl-phenyl)-acetyl]-azepan-4-ylcarbamoyl}-butyl)-amide

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Technology Process of 5-(2-Morpholin-4-yl-ethoxy)-benzofuran-2-carboxylic acid ((S)-3-methyl-1-{(R)-3-oxo-1-[2-(3-pyridin-2-yl-phenyl)-acetyl]-azepan-4-ylcarbamoyl}-butyl)-amide

There total 10 articles about 5-(2-Morpholin-4-yl-ethoxy)-benzofuran-2-carboxylic acid ((S)-3-methyl-1-{(R)-3-oxo-1-[2-(3-pyridin-2-yl-phenyl)-acetyl]-azepan-4-ylcarbamoyl}-butyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 150989-62-1
2,3,4,7-tetrahydro-azepine-1-carboxylic acid benzyl ester

: 281214-55-9
5-(2-Morpholin-4-yl-ethoxy)-benzofuran-2-carboxylic acid ((S)-3-methyl-1-{(R)-3-oxo-1-[2-(3-pyridin-2-yl-phenyl)-acetyl]-azepan-4-ylcarbamoyl}-butyl)-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: m-CPBA / CH₂Cl₂ / 0.25 h / 5 °C

2.1: NaN₃; NH₄Cl / H₂O; methanol / 70 °C

2.2: 61 percent / Et₃N; 1,3-propanedithiol / methanol / 20 °C

3.1: 77 percent / EDC; hydroxybenztriazole / CH₂Cl₂ / 20 °C

4.1: 97 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol

5.1: 86 percent / EDC; hydroxybenztriazole / CH₂Cl₂ / 20 °C

6.1: 85 percent / 4 M HCl / dioxane; methanol

7.1: 91 percent / EDC; hydroxybenztriazole / CH₂Cl₂ / 20 °C

8.1: SO₃-pyridine complex; TEA / dimethylsulfoxide / 2 h / 20 °C

With hydrogenchloride; sodium azide; pyridine-SO₃ complex; TEA; hydrogen; ammonium chloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 3-chloro-benzenecarboperoxoic acid; 10percent Pd/C; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jm000481x

Reference yield:

: 150989-61-0
4(R,S)-amino-3(R,S)-hydroxyazepane-1-carboxylic acid benzyl ester

: 281214-55-9
5-(2-Morpholin-4-yl-ethoxy)-benzofuran-2-carboxylic acid ((S)-3-methyl-1-{(R)-3-oxo-1-[2-(3-pyridin-2-yl-phenyl)-acetyl]-azepan-4-ylcarbamoyl}-butyl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / EDC; hydroxybenztriazole / CH₂Cl₂ / 20 °C

2: 97 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol

3: 86 percent / EDC; hydroxybenztriazole / CH₂Cl₂ / 20 °C

4: 85 percent / 4 M HCl / dioxane; methanol

5: 91 percent / EDC; hydroxybenztriazole / CH₂Cl₂ / 20 °C

6: SO₃-pyridine complex; TEA / dimethylsulfoxide / 2 h / 20 °C

With hydrogenchloride; pyridine-SO₃ complex; TEA; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 10percent Pd/C; In 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jm000481x

Reference yield:

: 150989-59-6
8-oxo-3-azabicyclo[5.1.0]octane-3-carboxylic acid benzyl ester

: 281214-55-9
5-(2-Morpholin-4-yl-ethoxy)-benzofuran-2-carboxylic acid ((S)-3-methyl-1-{(R)-3-oxo-1-[2-(3-pyridin-2-yl-phenyl)-acetyl]-azepan-4-ylcarbamoyl}-butyl)-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaN₃; NH₄Cl / H₂O; methanol / 70 °C

1.2: 61 percent / Et₃N; 1,3-propanedithiol / methanol / 20 °C

2.1: 77 percent / EDC; hydroxybenztriazole / CH₂Cl₂ / 20 °C

3.1: 97 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol

4.1: 86 percent / EDC; hydroxybenztriazole / CH₂Cl₂ / 20 °C

5.1: 85 percent / 4 M HCl / dioxane; methanol

6.1: 91 percent / EDC; hydroxybenztriazole / CH₂Cl₂ / 20 °C

7.1: SO₃-pyridine complex; TEA / dimethylsulfoxide / 2 h / 20 °C

With hydrogenchloride; sodium azide; pyridine-SO₃ complex; TEA; hydrogen; ammonium chloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 10percent Pd/C; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jm000481x