5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrazine-2-carboxamide

Base Information

Chemical Name:5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrazine-2-carboxamide
CAS No.:1352570-13-8
Molecular Formula:C₂₀H₂₁N₅O₄
Molecular Weight:395.418
Hs Code.:

Synonyms:5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrazine-2-carboxamide

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Chemical Property of 5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrazine-2-carboxamide

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Technology Process of 5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrazine-2-carboxamide

There total 8 articles about 5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352571-64-2
C₂₈H₂₉N₅O₅

: 1352570-13-8
5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrazine-2-carboxamide

Guidance literature:: C₂₈H₂₉N₅O₅; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 108-46-3
recorcinol

: 1352570-13-8
5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: 1H-imidazole / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tert-butyl methyl ether / 10 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed tube

4: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 70 °C / Inert atmosphere; Sealed tube

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

6: potassium carbonate / acetonitrile / 4 h / 75 °C

7: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide; acetonitrile; 4: Suzuki Coupling;

Reference yield:

: 68792-12-1
3-isopropoxyphenol

: 1352570-13-8
5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1H-imidazole / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tert-butyl methyl ether / 10 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed tube

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 70 °C / Inert atmosphere; Sealed tube

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

5: potassium carbonate / acetonitrile / 4 h / 75 °C

6: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; tert-butyl methyl ether; water; acetonitrile; 3: Suzuki Coupling;