N-((2-(3-methoxyphenyl)-5-oxotetrahydrofuran-2-yl)methyl)-4 nitrobenzenesulfonamide

Base Information

Chemical Name:N-((2-(3-methoxyphenyl)-5-oxotetrahydrofuran-2-yl)methyl)-4 nitrobenzenesulfonamide
CAS No.:1338575-82-8
Molecular Formula:C₁₈H₁₈N₂O₇S
Molecular Weight:406.416
Hs Code.:

Synonyms:N-((2-(3-methoxyphenyl)-5-oxotetrahydrofuran-2-yl)methyl)-4 nitrobenzenesulfonamide

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Chemical Property of N-((2-(3-methoxyphenyl)-5-oxotetrahydrofuran-2-yl)methyl)-4 nitrobenzenesulfonamide

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Technology Process of N-((2-(3-methoxyphenyl)-5-oxotetrahydrofuran-2-yl)methyl)-4 nitrobenzenesulfonamide

There total 2 articles about N-((2-(3-methoxyphenyl)-5-oxotetrahydrofuran-2-yl)methyl)-4 nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1338575-72-6
tert-butyl 4-(3-methoxyphenyl)pent-4-enoate

: 6325-93-5
p-nitrobenzenesulfonamide

: 1338575-82-8
N-((2-(3-methoxyphenyl)-5-oxotetrahydrofuran-2-yl)methyl)-4 nitrobenzenesulfonamide

Guidance literature:: tert-butyl 4-(3-methoxyphenyl)pent-4-enoate; With tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; In acetonitrile; at 20 ℃; for 0.166667h; Molecular sieve; Inert atmosphere;

p-nitrobenzenesulfonamide; With iodosylbenzene; In acetonitrile; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1021/ol202436a

Reference yield:

: 92975-38-7
4-bromo-4-pentenoic acid tert-butyl ester

: 1338575-82-8
N-((2-(3-methoxyphenyl)-5-oxotetrahydrofuran-2-yl)methyl)-4 nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: barium hydroxide octahydrate; palladium diacetate; triphenylphosphine / 1,2-dimethoxyethane; water / 4 h / 56 °C

2.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline] / acetonitrile / 0.17 h / 20 °C / Molecular sieve; Inert atmosphere

2.2: 48 h / 20 °C / Inert atmosphere

With tetrakis(actonitrile)copper(I) hexafluorophosphate; barium hydroxide octahydrate; palladium diacetate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; triphenylphosphine; In 1,2-dimethoxyethane; water; acetonitrile; 1.1: Suzuki coupling;
DOI:10.1021/ol202436a