2-[2-(6-cyano-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethoxy]ethyl benzoate

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Chemical Name:2-[2-(6-cyano-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethoxy]ethyl benzoate
CAS No.:1346176-26-8
Molecular Formula:C₂₄H₂₀N₄O₄
Molecular Weight:428.447
Hs Code.:

Synonyms:2-[2-(6-cyano-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethoxy]ethyl benzoate

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Chemical Property of 2-[2-(6-cyano-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethoxy]ethyl benzoate

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Technology Process of 2-[2-(6-cyano-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethoxy]ethyl benzoate

There total 9 articles about 2-[2-(6-cyano-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethoxy]ethyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 871027-22-4
2-{2-[(methylsulfonyl)oxy]ethoxy}ethyl benzoate

: 871027-37-1
4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine-6-carbonitrile

: 1346176-26-8
2-[2-(6-cyano-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethoxy]ethyl benzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 23h;
DOI:10.1021/jm2008634

Reference yield:

: C₁₃H₈ClN₃O₂

: 1346176-26-8
2-[2-(6-cyano-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethoxy]ethyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / tetrahydrofuran / 0 °C

2: trichlorophosphate / 1.5 h / 70 °C

3: potassium carbonate / N,N-dimethyl-formamide / 23 h / 60 °C

With ammonia; potassium carbonate; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm2008634

Reference yield:

: 871024-05-4
4-iodo-6-phenoxypyrimidine-5-amine

: 1346176-26-8
2-[2-(6-cyano-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethoxy]ethyl benzoate

Guidance literature:: Multi-step reaction with 8 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / acetonitrile / 16.5 h / 20 °C

2: potassium tert-butylate / tetrahydrofuran / 1.5 h / 0 - 20 °C

3: hydrogenchloride / tetrahydrofuran; water / 2 h / 20 °C

4: sodium dihydrogenphosphate; sodium chlorite / water; dimethyl sulfoxide / 2 h / 20 °C

5: thionyl chloride / 2 h / 75 °C

6: ammonia / tetrahydrofuran / 0 °C

7: trichlorophosphate / 1.5 h / 70 °C

8: potassium carbonate / N,N-dimethyl-formamide / 23 h / 60 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sodium chlorite; sodium dihydrogenphosphate; copper(l) iodide; thionyl chloride; potassium tert-butylate; ammonia; potassium carbonate; triethylamine; trichlorophosphate; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; 1: Sonogashira coupling;
DOI:10.1021/jm2008634