ethyl 4a,6-dimethyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,7a-tetrahydro-7H-pyrrolo[3,2-c]pyridazine-1-carboxylate

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Chemical Name:ethyl 4a,6-dimethyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,7a-tetrahydro-7H-pyrrolo[3,2-c]pyridazine-1-carboxylate
CAS No.:1380312-52-6
Molecular Formula:C₁₈H₂₁N₇O₂
Molecular Weight:367.41
Hs Code.:

Synonyms:ethyl 4a,6-dimethyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,7a-tetrahydro-7H-pyrrolo[3,2-c]pyridazine-1-carboxylate

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Chemical Property of ethyl 4a,6-dimethyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,7a-tetrahydro-7H-pyrrolo[3,2-c]pyridazine-1-carboxylate

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Technology Process of ethyl 4a,6-dimethyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,7a-tetrahydro-7H-pyrrolo[3,2-c]pyridazine-1-carboxylate

There total 3 articles about ethyl 4a,6-dimethyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,7a-tetrahydro-7H-pyrrolo[3,2-c]pyridazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 625-84-3
2,5-Dimethylpyrrole

: 1380312-44-6
ethyl 2-[2-bromo-1-(1-phenyl-1H-tetrazol-5-yl)ethylidene]hydrazinecarboxylate

: 1380312-52-6
ethyl 4a,6-dimethyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,7a-tetrahydro-7H-pyrrolo[3,2-c]pyridazine-1-carboxylate

Guidance literature:: With sodium carbonate; In dichloromethane; at 20 ℃; for 30h;
DOI:10.1002/ejoc.201101826

Reference yield:

: 343945-95-9
5-acetyl-1-phenyl-1H-tetrazole

: 1380312-52-6
ethyl 4a,6-dimethyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,7a-tetrahydro-7H-pyrrolo[3,2-c]pyridazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / toluene / 1 h / 120 °C / Inert atmosphere

2: N-Bromosuccinimide / chloroform / 16 h / 70 °C

3: sodium carbonate / dichloromethane / 30 h / 20 °C

With N-Bromosuccinimide; sodium carbonate; toluene-4-sulfonic acid; In dichloromethane; chloroform; toluene;
DOI:10.1002/ejoc.201101826

Reference yield:

: 1380312-43-5
ethyl 2-[1-(1-phenyl-1H-tetrazol-5-yl)ethylidene]hydrazinecarboxylate

: 1380312-52-6
ethyl 4a,6-dimethyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,7a-tetrahydro-7H-pyrrolo[3,2-c]pyridazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / chloroform / 16 h / 70 °C

2: sodium carbonate / dichloromethane / 30 h / 20 °C

With N-Bromosuccinimide; sodium carbonate; In dichloromethane; chloroform;
DOI:10.1002/ejoc.201101826