8-chloro-3-(cyclopropylmethyl)-7-[4-[2-fluoro-6-[¹¹C]methoxyphenyl]-1-piperidinyl]-1,2,4-triazolo[4,3-a]pyridine

Base Information

• Chemical Name: 8-chloro-3-(cyclopropylmethyl)-7-[4-[2-fluoro-6-[¹¹C]methoxyphenyl]-1-piperidinyl]-1,2,4-triazolo[4,3-a]pyridine
• CAS No.: 1376334-54-1
• Molecular Formula: C₂₂H₂₄ClFN₄O
• Molecular Weight: 413.899

Synonyms:8-chloro-3-(cyclopropylmethyl)-7-[4-[2-fluoro-6-[¹¹C]methoxyphenyl]-1-piperidinyl]-1,2,4-triazolo[4,3-a]pyridine

Chemical Property of 8-chloro-3-(cyclopropylmethyl)-7-[4-[2-fluoro-6-[¹¹C]methoxyphenyl]-1-piperidinyl]-1,2,4-triazolo[4,3-a]pyridine

Chemical Property:

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Technology Process of 8-chloro-3-(cyclopropylmethyl)-7-[4-[2-fluoro-6-[¹¹C]methoxyphenyl]-1-piperidinyl]-1,2,4-triazolo[4,3-a]pyridine

There total 2 articles about 8-chloro-3-(cyclopropylmethyl)-7-[4-[2-fluoro-6-[¹¹C]methoxyphenyl]-1-piperidinyl]-1,2,4-triazolo[4,3-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[11C]methyl iodide (54245-42-0) + 2-[1-[8-chloro-3-(cyclopropylmethyl)-1,2,4-triazolo[4,3-a]pyridin-7-yl]-4-piperidinyl]-3-fluoro-phenol (1376335-30-6) → 8-chloro-3-(cyclopropylmethyl)-7-[4-[2-fluoro-6-[11C]methoxyphenyl]-1-piperidinyl]-1,2,4-triazolo[4,3-a]pyridine (1376334-54-1)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 0.05h; Inert atmosphere;

DOI:10.1021/jm300912k

Reference yield:

→ 8-chloro-3-(cyclopropylmethyl)-7-[4-[2-fluoro-6-[11C]methoxyphenyl]-1-piperidinyl]-1,2,4-triazolo[4,3-a]pyridine (1376334-54-1)

Guidance literature:

upstream raw materials:

[11C]methyl iodide

2-[1-[8-chloro-3-(cyclopropylmethyl)-1,2,4-triazolo[4,3-a]pyridin-7-yl]-4-piperidinyl]-3-fluoro-phenol

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