(2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2,3-dimethylbutanoate

Base Information

Chemical Name:(2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2,3-dimethylbutanoate
CAS No.:154520-26-0
Molecular Formula:C₂₉H₅₂N₂O₄S
Molecular Weight:524.809
Hs Code.:

Synonyms:(2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2,3-dimethylbutanoate

Suppliers and Price of (2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2,3-dimethylbutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2,3-dimethylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2,3-dimethylbutanoate

There total 4 articles about (2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2,3-dimethylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 154520-16-8
(2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-cyano-2,3-dimethylbutanoate

: 154520-26-0
(2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2,3-dimethylbutanoate

Guidance literature:: With hydrogen; rhodium on alumina; In ethanol; ammonia; at 35 ℃; for 24h;
DOI:10.1021/jo00088a034

Reference yield:

: 22426-27-3
2-Cyano-3-methylbutanoic acid

: 154520-26-0
(2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2,3-dimethylbutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: PCl₅

2: 89 percent / AgCN / toluene / 4 h / 80 °C

3: 50 percent / LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, HMPA, -78 deg C to r.t.; r.t., 1 d

4: 91 percent / H₂ / 5percent Rh-Al₂O₃ / ethanol; NH₃ / 24 h / 35 °C

With silver cyanide; phosphorus pentachloride; hydrogen; lithium diisopropyl amide; rhodium on alumina; In ethanol; ammonia; toluene;
DOI:10.1021/jo00088a034

Reference yield:

: 98134-33-9
2-Cyano-3-methylbutanoyl chloride

: 154520-26-0
(2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2,3-dimethylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / AgCN / toluene / 4 h / 80 °C

2: 50 percent / LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, HMPA, -78 deg C to r.t.; r.t., 1 d

3: 91 percent / H₂ / 5percent Rh-Al₂O₃ / ethanol; NH₃ / 24 h / 35 °C

With silver cyanide; hydrogen; lithium diisopropyl amide; rhodium on alumina; In ethanol; ammonia; toluene;
DOI:10.1021/jo00088a034