(R)-N-[(4-{[4-(dimethylamino)-1-(phenylthio)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]-4-ethynylbenzamide

Base Information

Chemical Name:(R)-N-[(4-{[4-(dimethylamino)-1-(phenylthio)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]-4-ethynylbenzamide
CAS No.:1376191-22-8
Molecular Formula:C₂₇H₂₈N₄O₅S₂
Molecular Weight:552.675
Hs Code.:

Synonyms:(R)-N-[(4-{[4-(dimethylamino)-1-(phenylthio)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]-4-ethynylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-[(4-{[4-(dimethylamino)-1-(phenylthio)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]-4-ethynylbenzamide

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Technology Process of (R)-N-[(4-{[4-(dimethylamino)-1-(phenylthio)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]-4-ethynylbenzamide

There total 1 articles about (R)-N-[(4-{[4-(dimethylamino)-1-(phenylthio)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]-4-ethynylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 406233-35-0
4-(((1R)-3-(dimethylamino)-1-((phenylthio)methyl)propyl)amino)-3-nitrobenzenesulfonamide

: 10602-00-3
4-Ethynyl-benzoic acid

: 1376191-22-8
(R)-N-[(4-{[4-(dimethylamino)-1-(phenylthio)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]-4-ethynylbenzamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 8h; Inert atmosphere;
DOI:10.1021/jm300178u

Reference yield: 75.0%

: 1376191-22-8
(R)-N-[(4-{[4-(dimethylamino)-1-(phenylthio)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]-4-ethynylbenzamide

: 1376191-03-5
(S)-4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-3-(3-iodophenyl)-N-[3-(4-methylpiperazin-1-yl)propyl]-1H-pyrrole-2-carboxamide

: 1379604-78-0
4-(4-chlorophenyl)-1-[(S)-3,4-dihydroxybutyl]-3-{3-[(4-{[(4-{[(R)-4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-3-nitrophenyl)sulfonyl]carbamoyl}phenyl)ethynyl]phenyl}-N-[3-(4-methylpiperazin-1-yl)propyl]-1H-pyrrole-2-carboxamide

Guidance literature:: (R)-N-[(4-{[4-(dimethylamino)-1-(phenylthio)butan-2-yl]amino}-3-nitrophenyl)sulfonyl]-4-ethynylbenzamide; (S)-4-(4-chlorophenyl)-1-[2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl]-3-(3-iodophenyl)-N-[3-(4-methylpiperazin-1-yl)propyl]-1H-pyrrole-2-carboxamide; With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; at 20 - 40 ℃; for 3h; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;
DOI:10.1021/jm300178u