4-{[4-(5-fluoropyridin-3-yl)-1,3-thiazol-2-yl]methyl}-2,5-dimethylaniline

Base Information

Chemical Name:4-{[4-(5-fluoropyridin-3-yl)-1,3-thiazol-2-yl]methyl}-2,5-dimethylaniline
CAS No.:1421922-45-3
Molecular Formula:C₁₇H₁₆FN₃S
Molecular Weight:313.399
Hs Code.:

Synonyms:4-{[4-(5-fluoropyridin-3-yl)-1,3-thiazol-2-yl]methyl}-2,5-dimethylaniline

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Chemical Property of 4-{[4-(5-fluoropyridin-3-yl)-1,3-thiazol-2-yl]methyl}-2,5-dimethylaniline

Chemical Property:

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Technology Process of 4-{[4-(5-fluoropyridin-3-yl)-1,3-thiazol-2-yl]methyl}-2,5-dimethylaniline

There total 5 articles about 4-{[4-(5-fluoropyridin-3-yl)-1,3-thiazol-2-yl]methyl}-2,5-dimethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-[2-(2,5-dimethyl-4-nitrobenzyl)-1,3-thiazol-4-yl]-5-fluoropyridine dihydrobromide

: 1421922-45-3
4-{[4-(5-fluoropyridin-3-yl)-1,3-thiazol-2-yl]methyl}-2,5-dimethylaniline

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; at 40 ℃; for 26h;

Reference yield:

: 16213-85-7
(2,5-dimethylphenyl)acetonitrile

: 1421922-45-3
4-{[4-(5-fluoropyridin-3-yl)-1,3-thiazol-2-yl]methyl}-2,5-dimethylaniline

Guidance literature:: Multi-step reaction with 4 steps

1: nitric acid / 0.5 h / Cooling with ice

2: hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate / ethyl acetate / 24 h / 20 °C

3: isopropyl alcohol / 3.5 h / 80 °C

4: palladium 10% on activated carbon; hydrogen / ethanol / 26 h / 40 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; nitric acid; O,O-Diethyl hydrogen phosphorodithioate; In ethanol; ethyl acetate; isopropyl alcohol;

Reference yield:

: 1421922-03-3
(2,5-dimethyl-4-nitrophenyl)acetonitrile

: 1421922-45-3
4-{[4-(5-fluoropyridin-3-yl)-1,3-thiazol-2-yl]methyl}-2,5-dimethylaniline

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate / ethyl acetate / 24 h / 20 °C

2: isopropyl alcohol / 3.5 h / 80 °C

3: palladium 10% on activated carbon; hydrogen / ethanol / 26 h / 40 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; O,O-Diethyl hydrogen phosphorodithioate; In ethanol; ethyl acetate; isopropyl alcohol;