C₁₅H₂₆N₂O₃

Base Information

• Chemical Name: C₁₅H₂₆N₂O₃
• CAS No.: 1441792-39-7
• Molecular Formula: C₁₅H₂₆N₂O₃
• Molecular Weight: 282.383
• Mol file: 1441792-39-7.mol

Synonyms:C₁₅H₂₆N₂O₃

Chemical Property of C₁₅H₂₆N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₂₆N₂O₃

There total 1 articles about C₁₅H₂₆N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-methyl-1-ethyl-4-oxopiperidinium iodide (77542-18-8) + tert-butyl (3S)-3-aminopiperidine-1-carboxylate (625471-18-3) → C15H26N2O3 (1441792-39-7)

Guidance literature:

With potassium carbonate; In ethanol; water; at 80 ℃; for 4h;

Reference yield:

C15H26N2O3 (1441792-39-7) → 2-((S)-3-(4-(4-chloro-3-((R)-1-(2,4-dichlorophenyI)ethylamino)phenyl)-5,6-dihydropyridin-1(2H)-yl)piperidin-1-yI)acetic acid trifluoroacetate

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 - -20 °C / Inert atmosphere

1.2: 6 h / -78 - 20 °C / Inert atmosphere

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 5 h / 85 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 12 h / Inert atmosphere

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 50 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; trifluoroacetic acid; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

C15H26N2O3 (1441792-39-7) → C27H32Cl3N3O2 (1441792-54-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 - -20 °C / Inert atmosphere

1.2: 6 h / -78 - 20 °C / Inert atmosphere

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 5 h / 85 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 12 h / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; dichloromethane; water;

upstream raw materials:

1-methyl-1-ethyl-4-oxopiperidinium iodide

tert-butyl (3S)-3-aminopiperidine-1-carboxylate

Downstream raw materials:

2-chloro-N-((1R)-1-(2,4-dichIorophenyl)ethyl)-5-(1-((3S)-3-piperidyl)-3,6-dihydro-2H-pyridin-4-yl)aniline

C₂₇H₃₂Cl₃N₃O₂