L-3,5-dibromo-3'-<(6-chloropyridazin-3-yl)methyl>-4'-O-methyl-N-trifluoroacetylthyronine methyl ester

Base Information

• Chemical Name: L-3,5-dibromo-3'-<(6-chloropyridazin-3-yl)methyl>-4'-O-methyl-N-trifluoroacetylthyronine methyl ester
• CAS No.: 105190-12-3
• Molecular Formula: C₂₄H₁₉Br₂ClF₃N₃O₅
• Molecular Weight: 681.688

Synonyms:L-3,5-dibromo-3'-<(6-chloropyridazin-3-yl)methyl>-4'-O-methyl-N-trifluoroacetylthyronine methyl ester

Chemical Property of L-3,5-dibromo-3'-<(6-chloropyridazin-3-yl)methyl>-4'-O-methyl-N-trifluoroacetylthyronine methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

SDS file from LookChem

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Technology Process of L-3,5-dibromo-3'-<(6-chloropyridazin-3-yl)methyl>-4'-O-methyl-N-trifluoroacetylthyronine methyl ester

There total 7 articles about L-3,5-dibromo-3'-<(6-chloropyridazin-3-yl)methyl>-4'-O-methyl-N-trifluoroacetylthyronine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

bis<<3-<(6-chloropyridazin-3-yl)methyl>-4-methoxyphenyl>>iodonium trifluoroacetate (105190-14-5) + 3,5-dibromo-N-trifluoroacetyl-L-tyrosine methyl ester (105189-44-4) → 3-chloro-6-(5-iodo-2-methoxybenzyl)-pyridazine (116762-85-7) + L-3,5-dibromo-3'-<(6-chloropyridazin-3-yl)methyl>-4'-O-methyl-N-trifluoroacetylthyronine methyl ester (105190-12-3)

Guidance literature:

With copper; triethylamine; In dichloromethane; for 18h; Ambient temperature;

Reference yield:

<<3-<(6-chloropyridazin-3-yl)methyl>-4-methoxyphenyl>>-(4-metoxyphenyl)iodonium trifluoroacetate (116762-90-4) + 3,5-dibromo-N-trifluoroacetyl-L-tyrosine methyl ester (105189-44-4) → para-iodoanisole (696-62-8) + (S)-3-[3,5-Dibromo-4-(4-methoxy-phenoxy)-phenyl]-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester (116762-94-8) + L-3,5-dibromo-3'-<(6-chloropyridazin-3-yl)methyl>-4'-O-methyl-N-trifluoroacetylthyronine methyl ester (105190-12-3) + trifluoroacetic acid (76-05-1)

Guidance literature:

With copper; triethylamine; In dichloromethane; for 18h; Yield given; Ambient temperature;

Reference yield:

<<3-<(6-chloropyridazin-3-yl)methyl>-4-methoxyphenyl>>phenyliodonium trifluoroacetate (116762-88-0) + 3,5-dibromo-N-trifluoroacetyl-L-tyrosine methyl ester (105189-44-4) → iodobenzene (591-50-4) + (S)-3-(3,5-Dibromo-4-phenoxy-phenyl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester (116762-93-7) + L-3,5-dibromo-3'-<(6-chloropyridazin-3-yl)methyl>-4'-O-methyl-N-trifluoroacetylthyronine methyl ester (105190-12-3) + trifluoroacetic acid (76-05-1)

Guidance literature:

With copper; triethylamine; In dichloromethane; for 18h; Yield given; Ambient temperature;

upstream raw materials:

<<3-<(6-chloropyridazin-3-yl)methyl>-4-methoxyphenyl>>phenyliodonium trifluoroacetate

3,5-dibromo-N-trifluoroacetyl-L-tyrosine methyl ester

<<3-<(6-chloropyridazin-3-yl)methyl>-4-methoxyphenyl>>-(4-metoxyphenyl)iodonium trifluoroacetate

<<3-<(6-chloropyridazin-3-yl)methyl>-4-methoxyphenyl>>-(2,4-dimethoxyphenyl)iodonium trifluoroacetate

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