(R)-(1-hydroxy-6-phenoxy-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl)-acetic acid ethy; ester

Base Information

Chemical Name:(R)-(1-hydroxy-6-phenoxy-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl)-acetic acid ethy; ester
CAS No.:1196474-95-9
Molecular Formula:C₁₇H₁₇BO₅
Molecular Weight:312.13
Hs Code.:

Synonyms:(R)-(1-hydroxy-6-phenoxy-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl)-acetic acid ethy; ester

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Chemical Property of (R)-(1-hydroxy-6-phenoxy-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl)-acetic acid ethy; ester

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Technology Process of (R)-(1-hydroxy-6-phenoxy-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl)-acetic acid ethy; ester

There total 5 articles about (R)-(1-hydroxy-6-phenoxy-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl)-acetic acid ethy; ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59142-68-6
2-bromo-4-fluorobenzaldehyde

: 1196474-95-9
(R)-(1-hydroxy-6-phenoxy-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl)-acetic acid ethy; ester

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 - 100 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1.5 h / 80 °C / Inert atmosphere

3: ammonium chloride; zinc / tetrahydrofuran / 3.5 h / 20 °C

4: CHIRALPAK_.(R). IC column / ethanol; hexane; trifluoroacetic acid / 20 °C / Resolution of racemate

With potassium acetate; potassium carbonate; ammonium chloride; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; N,N-dimethyl-formamide; trifluoroacetic acid;

Reference yield:

: 1196473-74-1
(1-hydroxy-6-phenoxy-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl)-acetic acid ethyl ester

: 1196474-94-8
(S)-(1-hydroxy-6-phenoxy-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl)-acetic acid ethy; ester

: 1196474-95-9
(R)-(1-hydroxy-6-phenoxy-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl)-acetic acid ethy; ester

Guidance literature:: With CHIRALPAK IC column; In ethanol; hexane; trifluoroacetic acid; at 20 ℃; Resolution of racemate;

Reference yield:

: 1196474-92-6
2-bromo-4-phenoxybenzaldehyde

: 1196474-95-9
(R)-(1-hydroxy-6-phenoxy-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl)-acetic acid ethy; ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1.5 h / 80 °C / Inert atmosphere

2: ammonium chloride; zinc / tetrahydrofuran / 3.5 h / 20 °C

3: CHIRALPAK_.(R). IC column / ethanol; hexane; trifluoroacetic acid / 20 °C / Resolution of racemate

With potassium acetate; ammonium chloride; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; trifluoroacetic acid;