5-FLUORO-1,3-DIHYDRO-INDOLE-2-THIONE

Base Information

• Chemical Name: 5-FLUORO-1,3-DIHYDRO-INDOLE-2-THIONE
• CAS No.: 73425-13-5
• Molecular Formula: C8H6 F N S
• Molecular Weight: 167.207
• Mol file: 73425-13-5.mol

Synonyms:5-FLUORO-1,3-DIHYDRO-INDOLE-2-THIONE

Chemical Property of 5-FLUORO-1,3-DIHYDRO-INDOLE-2-THIONE

Chemical Property:

• Vapor Pressure: 0.0374mmHg at 25°C
• Refractive Index: 1.659
• Boiling Point: 240.7°C at 760 mmHg
• Flash Point: 99.4°C
• PSA: 44.12000
• Density: 1.37g/cm³
• LogP: 2.25910

Purity/Quality:

99% ^*data from raw suppliers

5-FLUORO-1,3-DIHYDRO-INDOLE-2-THIONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-FLUORO-1,3-DIHYDRO-INDOLE-2-THIONE

There total 3 articles about 5-FLUORO-1,3-DIHYDRO-INDOLE-2-THIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-fluoroindol-2(3H)-one (56341-41-4) → 5-fluoroindoline-2-thione (73425-13-5)

Guidance literature:

With tetraphosphorus decasulfide; sodium hydrogencarbonate; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1021/jo0479866

Reference yield:

5-fluoro-1H-indole-2,3-dione (443-69-6) → 5-fluoroindoline-2-thione (73425-13-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate; KOH / ethane-1,2-diol / 0.5 h / 70 °C

2: 90 percent / P₂S₅; NaHCO₃ / tetrahydrofuran / 4 h / 20 °C

With potassium hydroxide; tetraphosphorus decasulfide; sodium hydrogencarbonate; hydrazine hydrate; In tetrahydrofuran; ethylene glycol; 1: Wolf-Kishner reduction;

DOI:10.1021/jo0479866

Reference yield:

→ 5-fluoroindoline-2-thione (73425-13-5)

Guidance literature:

upstream raw materials:

5-fluoroindol-2(3H)-one

5-fluoro-1H-indole-2,3-dione

Refernces

• 1、 Rhodes, Steven,Short, Spencer,Sharma, Sidhika,Kaur, Ramneet,Jha, Mukund. "One-pot mild and efficient synthesis of [1,3]thiazino[3,2-: A] indol-4-ones and their anti-proliferative activity". supporting information. p. 3914 - 3920. Retrieved 2019/04/30.
• 2、 Pedras, M. Soledade C.,Jha, Mukund. "Concise syntheses of the cruciferous phytoalexins brassilexin, sinalexin, wasalexins, and analogues: Expanding the scope of the Vilsmeier formylation". . p. 1828 - 1834. Retrieved 2007/10/03.