[4-(2-Acetylsulfanyl-acetylamino)-benzoylamino]-acetic acid ethyl ester

Base Information

Chemical Name:[4-(2-Acetylsulfanyl-acetylamino)-benzoylamino]-acetic acid ethyl ester
CAS No.:95765-89-2
Molecular Formula:C₁₅H₁₈N₂O₅S
Molecular Weight:338.384
Hs Code.:

Synonyms:[4-(2-Acetylsulfanyl-acetylamino)-benzoylamino]-acetic acid ethyl ester

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Chemical Property of [4-(2-Acetylsulfanyl-acetylamino)-benzoylamino]-acetic acid ethyl ester

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Technology Process of [4-(2-Acetylsulfanyl-acetylamino)-benzoylamino]-acetic acid ethyl ester

There total 4 articles about [4-(2-Acetylsulfanyl-acetylamino)-benzoylamino]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 95765-88-1
[4-(2-Chloro-acetylamino)-benzoylamino]-acetic acid ethyl ester

: 10387-40-3
potassium thioacetate

: 95765-89-2
[4-(2-Acetylsulfanyl-acetylamino)-benzoylamino]-acetic acid ethyl ester

Guidance literature:: In ethanol; at 55 - 60 ℃; for 16h;
DOI:10.1021/jm00145a011

Reference yield:

: 4596-39-8
4-(2-chloroacetamido)benzoic acid

: 95765-89-2
[4-(2-Acetylsulfanyl-acetylamino)-benzoylamino]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / SOCl₂, pyridine / CHCl₃ / 2 h / 55 - 60 °C

2: 1.) NaHCO₃ / 1.) water, RT, 0.5 h, 2.) water, methanol, 16 h

3: 53 percent / ethanol / 16 h / 55 - 60 °C

With pyridine; thionyl chloride; sodium hydrogencarbonate; In ethanol; chloroform;
DOI:10.1021/jm00145a011

Reference yield:

: 150-13-0,159246-81-8,8014-65-1
4-amino-benzoic acid

: 95765-89-2
[4-(2-Acetylsulfanyl-acetylamino)-benzoylamino]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / NaOAc, K₂HPO₄ / acetic acid; CH₂Cl₂ / 16 h / 26 °C

2: 66 percent / SOCl₂, pyridine / CHCl₃ / 2 h / 55 - 60 °C

3: 1.) NaHCO₃ / 1.) water, RT, 0.5 h, 2.) water, methanol, 16 h

4: 53 percent / ethanol / 16 h / 55 - 60 °C

With pyridine; dipotassium hydrogenphosphate; thionyl chloride; sodium acetate; sodium hydrogencarbonate; In ethanol; dichloromethane; chloroform; acetic acid;
DOI:10.1021/jm00145a011