{3-[4-(3-Chloro-phenyl)-1,3-dimethyl-6,7-dihydro-1H-pyrazolo[3,4-e][1,4]diazepin-8-yl]-propyl}-dimethyl-amine

Base Information

Chemical Name:{3-[4-(3-Chloro-phenyl)-1,3-dimethyl-6,7-dihydro-1H-pyrazolo[3,4-e][1,4]diazepin-8-yl]-propyl}-dimethyl-amine
CAS No.:78451-70-4
Molecular Formula:C₁₉H₂₆ClN₅
Molecular Weight:359.902
Hs Code.:

Synonyms:{3-[4-(3-Chloro-phenyl)-1,3-dimethyl-6,7-dihydro-1H-pyrazolo[3,4-e][1,4]diazepin-8-yl]-propyl}-dimethyl-amine

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Chemical Property of {3-[4-(3-Chloro-phenyl)-1,3-dimethyl-6,7-dihydro-1H-pyrazolo[3,4-e][1,4]diazepin-8-yl]-propyl}-dimethyl-amine

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Technology Process of {3-[4-(3-Chloro-phenyl)-1,3-dimethyl-6,7-dihydro-1H-pyrazolo[3,4-e][1,4]diazepin-8-yl]-propyl}-dimethyl-amine

There total 4 articles about {3-[4-(3-Chloro-phenyl)-1,3-dimethyl-6,7-dihydro-1H-pyrazolo[3,4-e][1,4]diazepin-8-yl]-propyl}-dimethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 51022-73-2
4-(3-chloro-phenyl)-1,3-dimethyl-1,6,7,8-tetrahydro-pyrazolo[3,4-e][1,4]diazepine

: 109-54-6
3-(Dimethylamino)propyl chloride

: 78451-70-4
{3-[4-(3-Chloro-phenyl)-1,3-dimethyl-6,7-dihydro-1H-pyrazolo[3,4-e][1,4]diazepin-8-yl]-propyl}-dimethyl-amine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 60 ℃; for 16h;
DOI:10.1021/jm00140a013

Reference yield:

: 618-46-2
m-Chlorobenzoyl chloride

: 78451-70-4
{3-[4-(3-Chloro-phenyl)-1,3-dimethyl-6,7-dihydro-1H-pyrazolo[3,4-e][1,4]diazepin-8-yl]-propyl}-dimethyl-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 68 percent / Ca(OH)2 / dioxane / 1.5 h / Heating

2: 81 percent / POCl₃ / 6 h / Heating

3: 50 percent / 20 h / Heating

4: 20 percent / NaH / dimethylformamide / 16 h / 60 °C

With calcium hydroxide; sodium hydride; trichlorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00140a013

Reference yield:

: 58011-00-0
(1,3-dimethyl-5-hydroxy-1H-pyrazol-4-yl)(3-chlorophenyl)methanone

: 78451-70-4
{3-[4-(3-Chloro-phenyl)-1,3-dimethyl-6,7-dihydro-1H-pyrazolo[3,4-e][1,4]diazepin-8-yl]-propyl}-dimethyl-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / POCl₃ / 6 h / Heating

2: 50 percent / 20 h / Heating

3: 20 percent / NaH / dimethylformamide / 16 h / 60 °C

With sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00140a013