Multi-step reaction with 7 steps
1.1: N-Bromosuccinimide / acetonitrile / 0 - 20 °C
1.2: 0.17 h
2.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 50 - 80 °C
3.1: copper(l) iodide; tert.-butylnitrite / acetonitrile / 4.33 h / 75 °C
4.1: 1-methyl-pyrrolidin-2-one / 7 h / 170 °C
4.2: 0.33 h
5.1: hydrogenchloride; ethanol / 20 °C
6.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
6.3: pH 12
7.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere
7.2: 72 h / 20 °C
With
hydrogenchloride; N-Bromosuccinimide; copper(l) iodide; tert.-butylnitrite; ethanol; di-tert-butyl-diazodicarboxylate; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; N,N-dimethyl-formamide; acetonitrile;