4-[1-(2-(R)-acetylamino-3-phenyl-propionyl)-piperidin-4-yl]-N-hydroxy-butyramide

Base Information

Chemical Name:4-[1-(2-(R)-acetylamino-3-phenyl-propionyl)-piperidin-4-yl]-N-hydroxy-butyramide
CAS No.:910540-05-5
Molecular Formula:C₂₀H₂₉N₃O₄
Molecular Weight:375.468
Hs Code.:

Synonyms:4-[1-(2-(R)-acetylamino-3-phenyl-propionyl)-piperidin-4-yl]-N-hydroxy-butyramide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[1-(2-(R)-acetylamino-3-phenyl-propionyl)-piperidin-4-yl]-N-hydroxy-butyramide

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Technology Process of 4-[1-(2-(R)-acetylamino-3-phenyl-propionyl)-piperidin-4-yl]-N-hydroxy-butyramide

There total 2 articles about 4-[1-(2-(R)-acetylamino-3-phenyl-propionyl)-piperidin-4-yl]-N-hydroxy-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 108-24-7
acetic anhydride

: 910540-05-5
4-[1-(2-(R)-acetylamino-3-phenyl-propionyl)-piperidin-4-yl]-N-hydroxy-butyramide

Guidance literature:: acetic anhydride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18.33h;

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.583333h;

Reference yield: 75.0%

: 885274-47-5
4-[N-(fluoren-9-ylmethoxycarbonyl)piperidin-4-yl]-butanoic acid

: 108-24-7
acetic anhydride

: 86123-10-6
Fmoc-D-Phe-OH

: 910540-05-5
4-[1-(2-(R)-acetylamino-3-phenyl-propionyl)-piperidin-4-yl]-N-hydroxy-butyramide

Guidance literature:: 4-[N-(fluoren-9-ylmethoxycarbonyl)piperidin-4-yl]-butanoic acid; With 1-hydroxy-7-aza-benzotriazole; 2-chlorotrityl-N-Fmoc-hydroxylamine; diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h; N-Fmoc-hydroxylamine-2-chlorotrityl polystyrene

With 4-[N-(fluoren-9-ylmethoxycarbonyl)piperidin-4-yl]-butanoic acid; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 18h;

acetic anhydride; Fmoc-D-Phe-OH; With triethylsilane; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; diisopropyl-carbodiimide; N-Fmoc-hydroxylamine-2-chlorotrityl polystyrene more than 3 stages;