8-(4-(5-(aminomethyl)-2-fluorophenyl)piperidine-1-carbonyl)naphthalen-2-ylboronic acid hydrochloride

Base Information

Chemical Name:8-(4-(5-(aminomethyl)-2-fluorophenyl)piperidine-1-carbonyl)naphthalen-2-ylboronic acid hydrochloride
CAS No.:1411992-31-8
Molecular Formula:C₂₃H₂₄BFN₂O₃*ClH
Molecular Weight:442.726
Hs Code.:

Synonyms:8-(4-(5-(aminomethyl)-2-fluorophenyl)piperidine-1-carbonyl)naphthalen-2-ylboronic acid hydrochloride

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Chemical Property of 8-(4-(5-(aminomethyl)-2-fluorophenyl)piperidine-1-carbonyl)naphthalen-2-ylboronic acid hydrochloride

Chemical Property:

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Technology Process of 8-(4-(5-(aminomethyl)-2-fluorophenyl)piperidine-1-carbonyl)naphthalen-2-ylboronic acid hydrochloride

There total 4 articles about 8-(4-(5-(aminomethyl)-2-fluorophenyl)piperidine-1-carbonyl)naphthalen-2-ylboronic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.7%

: 1411992-63-6
C₃₄H₄₂BFN₂O₅

: 1411992-31-8
8-(4-(5-(aminomethyl)-2-fluorophenyl)piperidine-1-carbonyl)naphthalen-2-ylboronic acid hydrochloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 15h;

Reference yield:

: 93353-67-4
7-bromo-1-naphthoic acid methyl ester

: 1411992-31-8
8-(4-(5-(aminomethyl)-2-fluorophenyl)piperidine-1-carbonyl)naphthalen-2-ylboronic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 5 h / 80 °C / Inert atmosphere

2.1: lithium hydroxide; water / tetrahydrofuran / 8 h / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0.25 h / 0 °C

3.2: 4 h / 20 °C

4.1: hydrogenchloride / water; tetrahydrofuran / 15 h / 20 °C

With hydrogenchloride; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1290056-71-1
methyl 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-naphthoate

: 1411992-31-8
8-(4-(5-(aminomethyl)-2-fluorophenyl)piperidine-1-carbonyl)naphthalen-2-ylboronic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide; water / tetrahydrofuran / 8 h / 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0.25 h / 0 °C

2.2: 4 h / 20 °C

3.1: hydrogenchloride / water; tetrahydrofuran / 15 h / 20 °C

With hydrogenchloride; dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;