(R)-tert-butyl 4-(tert-butyldimethylsilyloxy)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Base Information

Chemical Name:(R)-tert-butyl 4-(tert-butyldimethylsilyloxy)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate
CAS No.:1380243-35-5
Molecular Formula:C₂₁H₃₄F₃NO₃Si
Molecular Weight:433.587
Hs Code.:

Synonyms:(R)-tert-butyl 4-(tert-butyldimethylsilyloxy)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

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Chemical Property of (R)-tert-butyl 4-(tert-butyldimethylsilyloxy)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Chemical Property:

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Technology Process of (R)-tert-butyl 4-(tert-butyldimethylsilyloxy)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

There total 8 articles about (R)-tert-butyl 4-(tert-butyldimethylsilyloxy)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 191655-45-5
(2S)‐2‐{[(tert‐butoxy)carbonyl]amino}‐4‐[(tert‐butyldimethylsilyl)oxy]butanoic acid

: 1380243-35-5
(R)-tert-butyl 4-(tert-butyldimethylsilyloxy)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide / ethyl acetate / 8 h / 0 - 20 °C

1.2: 0.08 h

2.1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 10 h / 0 - 20 °C / Inert atmosphere

3.1: tert-butylmagnesium bromide; copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.25 h / -20 - -5 °C / Inert atmosphere

3.2: 0.08 h

With 1-hydroxy-pyrrolidine-2,5-dione; copper(I) bromide dimethylsulfide complex; tert-butylmagnesium bromide; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; ethyl acetate;

Reference yield:

: 191655-46-6
tert-butyl (S)-(4-((tert-butyldimethylsilyl)oxy)-1-hydroxybutan-2-yl)carbamate

: 1380243-35-5
(R)-tert-butyl 4-(tert-butyldimethylsilyloxy)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 10 h / 0 - 20 °C / Inert atmosphere

2.1: tert-butylmagnesium bromide; copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.25 h / -20 - -5 °C / Inert atmosphere

2.2: 0.08 h

With copper(I) bromide dimethylsulfide complex; tert-butylmagnesium bromide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;

Reference yield:

: 474023-97-7
(2S)-amino-4-(tert-butyldimethylsilanyloxy)butanoic acid

: 1380243-35-5
(R)-tert-butyl 4-(tert-butyldimethylsilyloxy)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water; acetonitrile / 12 h / 0 - 20 °C

2.1: 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide / ethyl acetate / 8 h / 0 - 20 °C

2.2: 0.08 h

3.1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 10 h / 0 - 20 °C / Inert atmosphere

4.1: tert-butylmagnesium bromide; copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.25 h / -20 - -5 °C / Inert atmosphere

4.2: 0.08 h

With 1-hydroxy-pyrrolidine-2,5-dione; copper(I) bromide dimethylsulfide complex; tert-butylmagnesium bromide; dicyclohexyl-carbodiimide; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetonitrile;