(E)-4-(methylamino)-but-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]amide hydrochloride

Base Information

• Chemical Name: (E)-4-(methylamino)-but-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]amide hydrochloride
• CAS No.: 1245711-05-0
• Molecular Formula: C₂₃H₂₁ClFN₅O₂*ClH
• Molecular Weight: 490.364
• Mol file: 1245711-05-0.mol

Synonyms:(E)-4-(methylamino)-but-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]amide hydrochloride

Chemical Property of (E)-4-(methylamino)-but-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]amide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-4-(methylamino)-but-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]amide hydrochloride

There total 3 articles about (E)-4-(methylamino)-but-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

{(E)-3-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-ylcarbamoyl]-allyl}-methylcarbamic acid tert-butyl ester (915788-23-7) → (E)-4-(methylamino)-but-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]amide hydrochloride (1245711-05-0)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃;

DOI:10.1016/j.bmc.2010.08.004

Reference yield:

6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile (361162-95-0) → (E)-4-(methylamino)-but-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]amide hydrochloride (1245711-05-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trimethylaluminum / dichloromethane / 20 °C

2: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; trimethylaluminum; In 1,4-dioxane; dichloromethane;

Reference yield:

methyl (E)-4-(tert-butoxycarbonyl(methyl)amino)-but-2-enoate (915788-21-5) → (E)-4-(methylamino)-but-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]amide hydrochloride (1245711-05-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trimethylaluminum / dichloromethane / 20 °C

2: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; trimethylaluminum; In 1,4-dioxane; dichloromethane;

upstream raw materials:

{(E)-3-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-ylcarbamoyl]-allyl}-methylcarbamic acid tert-butyl ester

6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile

methyl (E)-4-(tert-butoxycarbonyl(methyl)amino)-but-2-enoate

Downstream raw materials:

(E)-4-[(2-fluoroethyl)methylamino]-but-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]amide

(E)-4-[(4-fluorobenzyl)methylamino]-but-2-enoic acid [4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl] amide