C₂₇H₃₄FN₆O₇PS

Base Information

• Chemical Name: C₂₇H₃₄FN₆O₇PS
• CAS No.: 1273029-53-0
• Molecular Formula: C₂₇H₃₄FN₆O₇PS
• Molecular Weight: 636.641
• Mol file: 1273029-53-0.mol

Synonyms:C₂₇H₃₄FN₆O₇PS

Chemical Property of C₂₇H₃₄FN₆O₇PS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₃₄FN₆O₇PS

There total 8 articles about C₂₇H₃₄FN₆O₇PS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C67H66FN6O9PS (1273029-52-9) → C27H34FN6O7PS (1273029-53-0)

Guidance literature:

With water; trifluoroacetic acid; In dichloromethane; at 25 - 60 ℃;

Reference yield:

C26H23FN4O6 → C27H34FN6O7PS (1273029-53-0)

Guidance literature:

Multi-step reaction with 6 steps

1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 73 h / 20 - 65 °C

2: water; ammonia / methanol / 16 h / 20 °C

3: chloro-trimethyl-silane; pyridine / 0 - 25 °C

4: pivaloyl chloride; pyridine / -30 - 0 °C

5: tetrachloromethane

6: trifluoroacetic acid; water / dichloromethane / 25 - 60 °C

With pyridine; chloro-trimethyl-silane; trimethylsilyl trifluoromethanesulfonate; ammonia; water; pivaloyl chloride; trifluoroacetic acid; In methanol; tetrachloromethane; dichloromethane; acetonitrile;

Reference yield:

((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate (874638-80-9,1033394-94-3) → C27H34FN6O7PS (1273029-53-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

1.2: 0.75 h

2.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 73 h / 20 - 65 °C

3.1: water; ammonia / methanol / 16 h / 20 °C

4.1: chloro-trimethyl-silane; pyridine / 0 - 25 °C

5.1: pivaloyl chloride; pyridine / -30 - 0 °C

6.1: tetrachloromethane

7.1: trifluoroacetic acid; water / dichloromethane / 25 - 60 °C

With pyridine; n-butyllithium; chloro-trimethyl-silane; trimethylsilyl trifluoromethanesulfonate; ammonia; water; pivaloyl chloride; trifluoroacetic acid; In tetrahydrofuran; methanol; tetrachloromethane; hexanes; dichloromethane; acetonitrile;

upstream raw materials:

((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate

7-bromo-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine

C₂₇H₂₂FN₅O₅

(2R,3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-carbonitrile