(R)-1-(4-bromophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Base Information

• Chemical Name: (R)-1-(4-bromophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
• CAS No.: 1120500-38-0
• Molecular Formula: C₁₈H₁₇BrN₂O
• Molecular Weight: 357.25
• Mol file: 1120500-38-0.mol

Synonyms:(R)-1-(4-bromophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Chemical Property of (R)-1-(4-bromophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-(4-bromophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

There total 1 articles about (R)-1-(4-bromophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-bromo-benzaldehyde (1122-91-4) + 2-(6-methoxy-1H-indol-3-yl)ethanamine (3610-36-4) → (R)-1-(4-bromophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (1120500-38-0)

Guidance literature:

With 1,1'-(2S,2'S)-1,1'-(4,10-dimethyl-1,4,7,10-tetraazacyclododecane-1,7-diyl)bis(3-methyl-1-oxobutane-2,1-diyl)bis(3-(3,5-bis(trifluoromethyl)phenyl)thiourea); 4-methoxybenzoic acid; In toluene; at 20 ℃; for 72h; enantioselective reaction;

DOI:10.1002/ejoc.202001501

Reference yield: 78.0%

di-tert-butyl dicarbonate (24424-99-5) + (R)-1-(4-bromophenyl)-7-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (1120500-38-0) → tert-butyl (R)-1-(4-bromophenyl)-7-methoxy-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate (1120500-77-7)

Guidance literature:

With sodium hydrogencarbonate; In water; ethyl acetate; at 20 ℃; for 2h;

DOI:10.1002/ejoc.202001501

upstream raw materials:

4-bromo-benzaldehyde

2-(6-methoxy-1H-indol-3-yl)ethanamine

Downstream raw materials:

tert-butyl (R)-1-(4-bromophenyl)-7-methoxy-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate