2,5'-dichloro-2'-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)-3,4'-bipyridin-5-amine

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Chemical Name:2,5'-dichloro-2'-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)-3,4'-bipyridin-5-amine
CAS No.:1378034-60-6
Molecular Formula:C₁₆H₁₆Cl₂FN₃O
Molecular Weight:356.227
Hs Code.:

Synonyms:2,5'-dichloro-2'-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)-3,4'-bipyridin-5-amine

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Chemical Property of 2,5'-dichloro-2'-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)-3,4'-bipyridin-5-amine

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Technology Process of 2,5'-dichloro-2'-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)-3,4'-bipyridin-5-amine

There total 1 articles about 2,5'-dichloro-2'-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)-3,4'-bipyridin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50675-18-8
3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

: 1378034-61-7
(6-chloro-pyridin-3-yl)-(tetrahydro-pyran-4-ylmethyl)-amine

: 1378034-60-6
2,5'-dichloro-2'-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)-3,4'-bipyridin-5-amine

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 20 h / 20 °C

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 3 h / 100 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dichloromethane;

Reference yield:

: N₁-((R)-3,3,3-trifluoro-2-methoxypropyl)cyclohexane-trans-1,4-diamine

: 1378034-60-6
2,5'-dichloro-2'-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)-3,4'-bipyridin-5-amine

: 76-05-1
trifluoroacetic acid

: 2,5'-dichloro-N₅-((tetrahydro-2H-pyran-4-yl)methyl)-N₂'-(trans-4-((R)-3,3,3-trifluoro-2-methoxypropylamino)cyclohexyl)-3,4'-bipyridine-2',5-diamine trifluoroacetate

Guidance literature:: N₁-((R)-3,3,3-trifluoro-2-methoxypropyl)cyclohexane-trans-1,4-diamine; 2,5'-dichloro-2'-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)-3,4'-bipyridin-5-amine; With 2,6-dimethylpyridine; In dimethyl sulfoxide; at 135 ℃; for 3h;

trifluoroacetic acid;

Reference yield:

: 1378034-60-6
2,5'-dichloro-2'-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)-3,4'-bipyridin-5-amine

: tert-butyl trans-4-aminocyclohexyl(tetrahydrofuran-3-yl)carbamate

: 76-05-1
trifluoroacetic acid

: 2,5'-dichloro-N₅-((tetrahydro-2H-pyran-4-yl)methyl)-N₂'-(trans-4-(tetrahydrofuran-3-ylamino)cyclohexyl)-3,4'-bipyridine-2',5-diamine trifluoroacetate

Guidance literature:: 2,5'-dichloro-2'-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)-3,4'-bipyridin-5-amine; tert-butyl trans-4-aminocyclohexyl(tetrahydrofuran-3-yl)carbamate; With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 48h;

trifluoroacetic acid; In dichloromethane; for 1h;