5'-O-(4,4'-dimethoxytrityl)-2-N-(2,2'-bis(2-nitrophenyl)ethyloxycarbonyl)-2'-deoxyguanosine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2-N-(2,2'-bis(2-nitrophenyl)ethyloxycarbonyl)-2'-deoxyguanosine
CAS No.:243657-16-1
Molecular Formula:C₄₆H₄₁N₇O₁₂
Molecular Weight:883.871
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2-N-(2,2'-bis(2-nitrophenyl)ethyloxycarbonyl)-2'-deoxyguanosine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2-N-(2,2'-bis(2-nitrophenyl)ethyloxycarbonyl)-2'-deoxyguanosine

Chemical Property:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2-N-(2,2'-bis(2-nitrophenyl)ethyloxycarbonyl)-2'-deoxyguanosine

There total 5 articles about 5'-O-(4,4'-dimethoxytrityl)-2-N-(2,2'-bis(2-nitrophenyl)ethyloxycarbonyl)-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 243657-13-8
2-N-(2,2'-bis(2-nitrophenyl)ethyloxycarbonyl)-2'-deoxyguanosine

: 243657-16-1
5'-O-(4,4'-dimethoxytrityl)-2-N-(2,2'-bis(2-nitrophenyl)ethyloxycarbonyl)-2'-deoxyguanosine

Guidance literature:: With pyridine; at 20 ℃;
DOI:10.1021/jo990479h

Reference yield:

: 51549-35-0
3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

: 243657-16-1
5'-O-(4,4'-dimethoxytrityl)-2-N-(2,2'-bis(2-nitrophenyl)ethyloxycarbonyl)-2'-deoxyguanosine

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / hexamethylphosphoric triamide; tert-butylmagnesium chloride / tetrahydrofuran / 4 h

2: tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

3: 60 percent / pyridine / 20 °C

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; tert-butylmagnesium chloride; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1: Acylation / 2: Hydrolysis / 3: Etherification;
DOI:10.1021/jo990479h

Reference yield:

: 189216-43-1
2,2'-bis(2-nitrophenyl)ethyl chloroformate

: 243657-16-1
5'-O-(4,4'-dimethoxytrityl)-2-N-(2,2'-bis(2-nitrophenyl)ethyloxycarbonyl)-2'-deoxyguanosine

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / hexamethylphosphoric triamide; tert-butylmagnesium chloride / tetrahydrofuran / 4 h

2: tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

3: 60 percent / pyridine / 20 °C

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; tert-butylmagnesium chloride; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1: Acylation / 2: Hydrolysis / 3: Etherification;
DOI:10.1021/jo990479h