N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-4-methylbenzene sulfonamide

Base Information

• Chemical Name: N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-4-methylbenzene sulfonamide
• CAS No.: 1427523-83-8
• Molecular Formula: C₁₆H₁₅F₂NO₂S
• Molecular Weight: 323.363

Synonyms:N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-4-methylbenzene sulfonamide

Chemical Property of N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-4-methylbenzene sulfonamide

Chemical Property:

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Technology Process of N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-4-methylbenzene sulfonamide

There total 1 articles about N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-4-methylbenzene sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine (1006614-49-8,220352-38-5,1459719-81-3) + p-toluenesulfonyl chloride (98-59-9) → N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-4-methylbenzene sulfonamide (1427523-83-8)

Guidance literature:

With triethylamine; In dichloromethane; for 1.5h; Cooling with ice;

Reference yield: 75.0%

(3aR,4S,6R,6aS)-6-(7-chloro-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol (220241-61-2) + N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-4-methylbenzene sulfonamide (1427523-83-8) → N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-N-(3-((3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)-4-methylbenzenesulfonamide (1427523-89-4)

Guidance literature:

With potassium phosphate; In acetonitrile; at 25 ℃; for 24h;

Reference yield: 49.0%

4,6-dichloro-5-nitro-2-(propylsulfanyl)pyrimidine (145783-14-8) + N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-4-methylbenzene sulfonamide (1427523-83-8) → N-(6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)-N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-4-methylbenzenesulfonamide (1427523-85-0)

Guidance literature:

With potassium phosphate; In acetonitrile; at 25 ℃; for 24h;

upstream raw materials:

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine

p-toluenesulfonyl chloride

Downstream raw materials:

N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-N-(3-((3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)-4-methylbenzenesulfonamide

N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-N-(6-(((3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)amino)-5-nitro-2-(propylthio)pyrimidin-4-yl)-4-methylbenzenesulfonamide

N-(5-amino-6-(((3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)amino)-2-(propylthio)pyrimidin-4-yl)-N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-4-methylbenzenesulfonamide

N-(6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)-N-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)-4-methylbenzenesulfonamide

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