7-methyl-1h-indole-3-carbpxylic acid methyl ester

Base Information

• Chemical Name: 7-methyl-1h-indole-3-carbpxylic acid methyl ester
• CAS No.: 773134-49-9
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.214
• Hs Code.: 2933990090
• Mol file: 773134-49-9.mol

Synonyms:7-methyl-1h-indole-3-carbpxylic acid methyl ester

Chemical Property of 7-methyl-1h-indole-3-carbpxylic acid methyl ester

Chemical Property:

• Vapor Pressure: 9.43E-05mmHg at 25°C
• Refractive Index: 1.624
• Boiling Point: 339.1°C at 760 mmHg
• Flash Point: 158.9°C
• PSA: 42.09000
• Density: 1.212
• LogP: 2.26290
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

methyl7-methyl-1H-indole-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-methyl-1h-indole-3-carbpxylic acid methyl ester

There total 1 articles about 7-methyl-1h-indole-3-carbpxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H19NO3 → 9-fluorenone (486-25-9,952573-42-1) + methyl 7-methyl-1H-indole-3-carboxylate (773134-49-9)

Guidance literature:

With oxalic acid adsorbed on silica gel; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1055/s-0035-1560210

Reference yield:

methyl 7-methyl-1H-indole-3-carboxylate (773134-49-9) → 1,7-dimethyl-1H-indole-3-carboxylic acid (125818-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: methanol; sodium hydroxide / Reflux

With methanol; potassium carbonate; sodium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2014.11.008

Reference yield:

methyl 7-methyl-1H-indole-3-carboxylate (773134-49-9) → 1,7-Dimethyl-1H-indole-3-carbonyl chloride

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: methanol; sodium hydroxide / Reflux

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

With methanol; oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2014.11.008

Downstream raw materials:

1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carboxylic acid

1,7-dimethyl-1H-indole-3-carboxylic acid

Refernces