(R)-1,1-dimethylethyl [3-[1-hydroxy-3-(4-morpholinyl)propyl]phenoxy]acetate

Base Information

• Chemical Name: (R)-1,1-dimethylethyl [3-[1-hydroxy-3-(4-morpholinyl)propyl]phenoxy]acetate
• CAS No.: 195202-13-2
• Molecular Formula: C₁₉H₂₉NO₅
• Molecular Weight: 351.443
• Mol file: 195202-13-2.mol

Synonyms:(R)-1,1-dimethylethyl [3-[1-hydroxy-3-(4-morpholinyl)propyl]phenoxy]acetate

Chemical Property of (R)-1,1-dimethylethyl [3-[1-hydroxy-3-(4-morpholinyl)propyl]phenoxy]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1,1-dimethylethyl [3-[1-hydroxy-3-(4-morpholinyl)propyl]phenoxy]acetate

There total 3 articles about (R)-1,1-dimethylethyl [3-[1-hydroxy-3-(4-morpholinyl)propyl]phenoxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

[3-(3-morpholin-4-yl-propionyl)-phenoxy]-acetic acid tert-butyl ester (195202-12-1) → (R)-1,1-dimethylethyl [3-[1-hydroxy-3-(4-morpholinyl)propyl]phenoxy]acetate (195202-13-2)

Guidance literature:

With B-chlorodiisopinocampheylborane; In tetrahydrofuran; at -20 ℃;

DOI:10.1016/S0968-0896(98)00125-4

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) → (R)-1,1-dimethylethyl [3-[1-hydroxy-3-(4-morpholinyl)propyl]phenoxy]acetate (195202-13-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / K₂CO₃ / acetone / 20 h / 20 °C

2: 27 percent / (+)-DIP-chloride / tetrahydrofuran / -20 °C

With potassium carbonate; B-chlorodiisopinocampheylborane; In tetrahydrofuran; acetone; 1: Alkylation / 2: Reduction;

DOI:10.1016/S0968-0896(98)00125-4

Reference yield:

1-(3-hydroxyphenyl)-3-(4-morpholinyl)-1-propanone (195202-11-0) → (R)-1,1-dimethylethyl [3-[1-hydroxy-3-(4-morpholinyl)propyl]phenoxy]acetate (195202-13-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / K₂CO₃ / acetone / 20 h / 20 °C

2: 27 percent / (+)-DIP-chloride / tetrahydrofuran / -20 °C

With potassium carbonate; B-chlorodiisopinocampheylborane; In tetrahydrofuran; acetone; 1: Alkylation / 2: Reduction;

DOI:10.1016/S0968-0896(98)00125-4

upstream raw materials:

[3-(3-morpholin-4-yl-propionyl)-phenoxy]-acetic acid tert-butyl ester

bromoacetic acid tert-butyl ester

1-(3-hydroxyphenyl)-3-(4-morpholinyl)-1-propanone

Downstream raw materials:

(S)-1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carboxylic acid (R)-1-(3-carboxymethoxy-phenyl)-3-morpholin-4-yl-propyl ester

(1R)-1-[3-[2-(1,1-dimethylethoxy)-2-oxoethoxy]phenyl-3-(4-morpholinyl)-1-propanyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-piperidinecarboxylate