N-[(1R,2S)-1-({[5-[(dimethylamino)methyl]-2-ethoxyphenyl]amino}carbonyl)-2-(1H-indol-3-yl)propyl]-4-(4-fluoro-2-methylphenyl)-3-oxopiperazine-1-carboxamide

Base Information

Chemical Name:N-[(1R,2S)-1-({[5-[(dimethylamino)methyl]-2-ethoxyphenyl]amino}carbonyl)-2-(1H-indol-3-yl)propyl]-4-(4-fluoro-2-methylphenyl)-3-oxopiperazine-1-carboxamide
CAS No.:697308-68-2
Molecular Formula:C₃₅H₄₁FN₆O₄
Molecular Weight:628.747
Hs Code.:

N-[(1R,2S)-1-({[5-[(dimethylamino)methyl]-2-ethoxyphenyl]amino}carbonyl)-2-(1H-indol-3-yl)propyl]-4-(4-fluoro-2-methylphenyl)-3-oxopiperazine-1-carboxamide

Synonyms:N-[(1R,2S)-1-({[5-[(dimethylamino)methyl]-2-ethoxyphenyl]amino}carbonyl)-2-(1H-indol-3-yl)propyl]-4-(4-fluoro-2-methylphenyl)-3-oxopiperazine-1-carboxamide

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Chemical Property of N-[(1R,2S)-1-({[5-[(dimethylamino)methyl]-2-ethoxyphenyl]amino}carbonyl)-2-(1H-indol-3-yl)propyl]-4-(4-fluoro-2-methylphenyl)-3-oxopiperazine-1-carboxamide

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Technology Process of N-[(1R,2S)-1-({[5-[(dimethylamino)methyl]-2-ethoxyphenyl]amino}carbonyl)-2-(1H-indol-3-yl)propyl]-4-(4-fluoro-2-methylphenyl)-3-oxopiperazine-1-carboxamide

There total 12 articles about N-[(1R,2S)-1-({[5-[(dimethylamino)methyl]-2-ethoxyphenyl]amino}carbonyl)-2-(1H-indol-3-yl)propyl]-4-(4-fluoro-2-methylphenyl)-3-oxopiperazine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4-ethoxy-3-aminobenzyl)dimethylamine

: 697305-34-3
(2R,3S)-2-({[4-(4-fluoro-2-methylphenyl)-3-oxopiperazin-1-yl]carbonyl}amino)-3-(1H-indol-3-yl)butanoic acid

: 697308-68-2
N-[(1R,2S)-1-({[5-[(dimethylamino)methyl]-2-ethoxyphenyl]amino}carbonyl)-2-(1H-indol-3-yl)propyl]-4-(4-fluoro-2-methylphenyl)-3-oxopiperazine-1-carboxamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile; at 20 ℃;
DOI:10.1016/j.bmc.2017.09.031

Reference yield:

: 697305-56-9
4-ethoxy-N,N-dimethyl-3-nitrobenzamide

: 697308-68-2
N-[(1R,2S)-1-({[5-[(dimethylamino)methyl]-2-ethoxyphenyl]amino}carbonyl)-2-(1H-indol-3-yl)propyl]-4-(4-fluoro-2-methylphenyl)-3-oxopiperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: borane-THF / tetrahydrofuran / Reflux

2: palladium 10% on activated carbon; hydrazine hydrate / ethanol / 20 °C

3: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; acetonitrile / 20 °C

With borane-THF; palladium 10% on activated carbon; benzotriazol-1-ol; hydrazine hydrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1016/j.bmc.2017.09.031

Reference yield:

: 697304-06-6
(4-ethoxy-3-nitrobenzyl)dimethylamine

: 697308-68-2
N-[(1R,2S)-1-({[5-[(dimethylamino)methyl]-2-ethoxyphenyl]amino}carbonyl)-2-(1H-indol-3-yl)propyl]-4-(4-fluoro-2-methylphenyl)-3-oxopiperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrazine hydrate / ethanol / 20 °C

2: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; acetonitrile / 20 °C

With palladium 10% on activated carbon; benzotriazol-1-ol; hydrazine hydrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1016/j.bmc.2017.09.031