(E)-2-Acetyl-8-(3-isopropyl-2-methoxy-phenyl)-5-methyl-oct-5-enoic acid ethyl ester

Base Information

Chemical Name:(E)-2-Acetyl-8-(3-isopropyl-2-methoxy-phenyl)-5-methyl-oct-5-enoic acid ethyl ester
CAS No.:80865-60-7
Molecular Formula:C₂₃H₃₄O₄
Molecular Weight:374.521
Hs Code.:

Synonyms:(E)-2-Acetyl-8-(3-isopropyl-2-methoxy-phenyl)-5-methyl-oct-5-enoic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2-Acetyl-8-(3-isopropyl-2-methoxy-phenyl)-5-methyl-oct-5-enoic acid ethyl ester

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Technology Process of (E)-2-Acetyl-8-(3-isopropyl-2-methoxy-phenyl)-5-methyl-oct-5-enoic acid ethyl ester

There total 8 articles about (E)-2-Acetyl-8-(3-isopropyl-2-methoxy-phenyl)-5-methyl-oct-5-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 141-97-9
ethyl acetoacetate

: 80865-66-3
1-((E)-6-Bromo-4-methyl-hex-3-enyl)-3-isopropyl-2-methoxy-benzene

: 80865-60-7
(E)-2-Acetyl-8-(3-isopropyl-2-methoxy-phenyl)-5-methyl-oct-5-enoic acid ethyl ester

Guidance literature:: With lithium hydride; In N,N-dimethyl-formamide; at 75 ℃;
DOI:10.1021/ja00370a077

Reference yield:

: 88-69-7
2-(1-methylethyl)phenol

: 80865-60-7
(E)-2-Acetyl-8-(3-isopropyl-2-methoxy-phenyl)-5-methyl-oct-5-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / NaH / tetrahydrofuran / Ambient temperature

2: 1.) n-BuLi / 1.) TMEDA, room temperature

3: 90 percent / PBr₃ / diethyl ether / 0 °C

4: 99 percent / NaH / tetrahydrofuran / 0 deg C -> room temperature

5: 1.) Ba(OH)2 / 2.) H₂O, Et₂O, 90 deg C, 17 h

6: LAH / diethyl ether / 0 °C

7: 1.) PBr₃, LiBr, collidine, 2.) ZnBr₂ / 1.) Et₂O, -40 - 0 deg C, 2.) 0 deg C

8: 90 percent / LiH / dimethylformamide / 75 °C

With 2,3,5-trimethyl-pyridine; barium dihydroxide; lithium aluminium tetrahydride; n-butyllithium; phosphorus tribromide; lithium hydride; sodium hydride; lithium bromide; zinc dibromide; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/ja00370a077

Reference yield:

: 2944-47-0
o-isopropylanisole

: 80865-60-7
(E)-2-Acetyl-8-(3-isopropyl-2-methoxy-phenyl)-5-methyl-oct-5-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) n-BuLi / 1.) TMEDA, room temperature

2: 90 percent / PBr₃ / diethyl ether / 0 °C

3: 99 percent / NaH / tetrahydrofuran / 0 deg C -> room temperature

4: 1.) Ba(OH)2 / 2.) H₂O, Et₂O, 90 deg C, 17 h

5: LAH / diethyl ether / 0 °C

6: 1.) PBr₃, LiBr, collidine, 2.) ZnBr₂ / 1.) Et₂O, -40 - 0 deg C, 2.) 0 deg C

7: 90 percent / LiH / dimethylformamide / 75 °C

With 2,3,5-trimethyl-pyridine; barium dihydroxide; lithium aluminium tetrahydride; n-butyllithium; phosphorus tribromide; lithium hydride; sodium hydride; lithium bromide; zinc dibromide; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/ja00370a077