(1R,3R)-N-benzyl-6-(5'-isopropoxy-4'-methoxy-2'-methyl-8'-naphthyl)-8-methoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(1R,3R)-N-benzyl-6-(5'-isopropoxy-4'-methoxy-2'-methyl-8'-naphthyl)-8-methoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:183787-78-2
Molecular Formula:C₃₄H₃₉NO₃
Molecular Weight:509.689
Hs Code.:

Synonyms:(1R,3R)-N-benzyl-6-(5'-isopropoxy-4'-methoxy-2'-methyl-8'-naphthyl)-8-methoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of (1R,3R)-N-benzyl-6-(5'-isopropoxy-4'-methoxy-2'-methyl-8'-naphthyl)-8-methoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline

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Technology Process of (1R,3R)-N-benzyl-6-(5'-isopropoxy-4'-methoxy-2'-methyl-8'-naphthyl)-8-methoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline

There total 2 articles about (1R,3R)-N-benzyl-6-(5'-isopropoxy-4'-methoxy-2'-methyl-8'-naphthyl)-8-methoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: Tributyl-(4-isopropoxy-5-methoxy-7-methyl-naphthalen-1-yl)-stannane

: 177555-90-7
Trifluoro-methanesulfonic acid (1R,3R)-2-benzyl-8-methoxy-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinolin-6-yl ester

: 183787-78-2
(1R,3R)-N-benzyl-6-(5'-isopropoxy-4'-methoxy-2'-methyl-8'-naphthyl)-8-methoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; 2,6-di-tert-butyl-4-methyl-phenol; triphenylphosphine; lithium chloride; copper(I) bromide; In N,N-dimethyl-formamide; at 120 ℃; for 28h;
DOI:10.1016/0040-4020(96)00813-7

Reference yield:

: 104292-12-8
(1R,3R)-2-Benzyl-8-methoxy-1,3-dimethyl-1,2,3,4-tetrahydro-isoquinolin-6-ol

: 183787-78-2
(1R,3R)-N-benzyl-6-(5'-isopropoxy-4'-methoxy-2'-methyl-8'-naphthyl)-8-methoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) TlOEt / 1.) CH₂Cl₂, 15 min, RT, 2.) CH₂Cl₂, RT, 5 min

2: 63 percent / PPh₃, PdCl₂(PPh₃)2, LiCl, CuBr, 2,6-di-tert-butyl-4-methylphenol / dimethylformamide / 28 h / 120 °C

With bis-triphenylphosphine-palladium(II) chloride; 2,6-di-tert-butyl-4-methyl-phenol; thallium (I) ethoxide; triphenylphosphine; lithium chloride; copper(I) bromide; In N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(96)00813-7