2,3,6,7-tetrahydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-8-one

Base Information

• Chemical Name: 2,3,6,7-tetrahydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-8-one
• CAS No.: 87372-43-8
• Molecular Formula: C₂₆H₂₆N₂O₄S
• Molecular Weight: 462.569
• Mol file: 87372-43-8.mol

Synonyms:2,3,6,7-tetrahydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-8-one

Chemical Property of 2,3,6,7-tetrahydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-8-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,6,7-tetrahydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-8-one

There total 3 articles about 2,3,6,7-tetrahydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,3,6,7-tetrahydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-8-thione (87372-42-7) → 2,3,6,7-tetrahydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-8-one (87372-43-8)

Guidance literature:

With Et₃⁽¹⁺⁾*BF₄^(1-); In dichloromethane; at 25 ℃; for 1h;

DOI:10.1021/ja00262a005

Reference yield:

(+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-8-one (80664-35-3) → 2,3,6,7-tetrahydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-8-one (87372-43-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / Lawesson reagent / toluene / 2.5 h / 90 °C

2: 92 percent / p-toluenesulfinyl chloride, i-Pr₂NEt / CH₂Cl₂ / 6 h / 65 °C

3: 80 percent / Et₃⁽¹⁺⁾*BF₄^(1-) / CH₂Cl₂ / 1 h / 25 °C

With Lawessons reagent; 4-methylbenzenesulfinyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;

DOI:10.1021/ja00262a005

Reference yield:

2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-8-thione (87372-41-6) → 2,3,6,7-tetrahydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-8-one (87372-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / p-toluenesulfinyl chloride, i-Pr₂NEt / CH₂Cl₂ / 6 h / 65 °C

2: 80 percent / Et₃⁽¹⁺⁾*BF₄^(1-) / CH₂Cl₂ / 1 h / 25 °C

With 4-methylbenzenesulfinyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1021/ja00262a005

upstream raw materials:

2,3,6,7-tetrahydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-8-thione

(+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-8-one

2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-8-thione