4,6-Dichloro-1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-1H-pyrrolo<3,2-c>pyridine

Base Information

Chemical Name:4,6-Dichloro-1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-1H-pyrrolo<3,2-c>pyridine
CAS No.:120552-25-2
Molecular Formula:C₃₃H₃₀Cl₂N₂O₄
Molecular Weight:589.518
Hs Code.:

Synonyms:4,6-Dichloro-1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-1H-pyrrolo<3,2-c>pyridine

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Chemical Property of 4,6-Dichloro-1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-1H-pyrrolo<3,2-c>pyridine

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Technology Process of 4,6-Dichloro-1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-1H-pyrrolo<3,2-c>pyridine

There total 7 articles about 4,6-Dichloro-1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-1H-pyrrolo<3,2-c>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 120552-24-1
4,6-Dichloro-1-(2-deoxy-β-D-erythro-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-3'-O-phenoxythiocarbonyl-1H-pyrrolo<3,2-c>pyridine

: 120552-25-2
4,6-Dichloro-1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-1H-pyrrolo<3,2-c>pyridine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 80 ℃; for 3h;
DOI:10.1055/s-1988-27759

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 120552-25-2
4,6-Dichloro-1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-1H-pyrrolo<3,2-c>pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / ethyldiisopropylamine / pyridine / 1 h / Ambient temperature

2: 84 percent / 4-dimethylaminopyridine / acetonitrile / 16 h / Ambient temperature

3: 85 percent / AIBN, tributylstannane / toluene / 3 h / 80 °C

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; N-ethyl-N,N-diisopropylamine; In pyridine; toluene; acetonitrile;
DOI:10.1055/s-1988-27759

Reference yield:

: 4330-21-6
2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

: 120552-25-2
4,6-Dichloro-1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-1H-pyrrolo<3,2-c>pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / KOH, cryptand TDA-1 / acetonitrile / 0.75 h / Ambient temperature

2: 72 percent / NH₃ / methanol / 12 h / 50 °C

3: 74 percent / ethyldiisopropylamine / pyridine / 1 h / Ambient temperature

4: 84 percent / 4-dimethylaminopyridine / acetonitrile / 16 h / Ambient temperature

5: 85 percent / AIBN, tributylstannane / toluene / 3 h / 80 °C

With dmap; potassium hydroxide; 2,2'-azobis(isobutyronitrile); cryptand TDA-1; ammonia; tri-n-butyl-tin hydride; N-ethyl-N,N-diisopropylamine; In pyridine; methanol; toluene; acetonitrile;
DOI:10.1055/s-1988-27759