(Z)-isopropyl 3-(3-(3-fluoro-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

Base Information

Chemical Name:(Z)-isopropyl 3-(3-(3-fluoro-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
CAS No.:1333152-17-2
Molecular Formula:C₁₅H₁₃F₄N₃O₂
Molecular Weight:343.281
Hs Code.:

Synonyms:(Z)-isopropyl 3-(3-(3-fluoro-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-isopropyl 3-(3-(3-fluoro-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

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Technology Process of (Z)-isopropyl 3-(3-(3-fluoro-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

There total 3 articles about (Z)-isopropyl 3-(3-(3-fluoro-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.86%

: 1388842-43-0
isopropyl 3-iodoacrylate

: 1333154-07-6
C₉H₅F₄N₃

: 1333152-17-2
(Z)-isopropyl 3-(3-(3-fluoro-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

Guidance literature:: With sodium hydroxide; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 3h; Inert atmosphere;

Reference yield:

: 149793-69-1
3-fluoro-5-trifluoromethyl-benzonitrile

: 1333152-17-2
(Z)-isopropyl 3-(3-(3-fluoro-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogen sulfide; magnesium(II) chloride hexahydrate / N,N-dimethyl-formamide / 25 - 30 °C

2.1: hydrazine hydrate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.2: 3 h / 85 - 90 °C / Inert atmosphere

3.1: sodium hydroxide / N,N-dimethyl-formamide / 3 h / 0 - 5 °C / Inert atmosphere

With sodium hydrogen sulfide; magnesium(II) chloride hexahydrate; hydrazine hydrate; sodium hydroxide; In N,N-dimethyl-formamide;

Reference yield:

: 1333154-06-5
C₈H₅F₄NS

: 1333152-17-2
(Z)-isopropyl 3-(3-(3-fluoro-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

1.2: 3 h / 85 - 90 °C / Inert atmosphere

2.1: sodium hydroxide / N,N-dimethyl-formamide / 3 h / 0 - 5 °C / Inert atmosphere

With hydrazine hydrate; sodium hydroxide; In N,N-dimethyl-formamide;