2-(3-[[4-(morpholin-4-yl)cyclohexyl]amino]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2⁽⁷⁾,3,5-tetraene-12-sulfonyl)ethan-1-ol

Base Information

• Chemical Name: 2-(3-[[4-(morpholin-4-yl)cyclohexyl]amino]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2⁽⁷⁾,3,5-tetraene-12-sulfonyl)ethan-1-ol
• CAS No.: 1447952-43-3
• Molecular Formula: C₂₁H₃₁N₅O₄S₂
• Molecular Weight: 481.64

Synonyms:2-(3-[[4-(morpholin-4-yl)cyclohexyl]amino]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2⁽⁷⁾,3,5-tetraene-12-sulfonyl)ethan-1-ol

Chemical Property of 2-(3-[[4-(morpholin-4-yl)cyclohexyl]amino]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2⁽⁷⁾,3,5-tetraene-12-sulfonyl)ethan-1-ol

Chemical Property:

Purity/Quality:

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Technology Process of 2-(3-[[4-(morpholin-4-yl)cyclohexyl]amino]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2⁽⁷⁾,3,5-tetraene-12-sulfonyl)ethan-1-ol

There total 9 articles about 2-(3-[[4-(morpholin-4-yl)cyclohexyl]amino]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2⁽⁷⁾,3,5-tetraene-12-sulfonyl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

C22H31N5O5S2 (1447956-84-4) → 2-(3-[[4-(morpholin-4-yl)cyclohexyl]amino]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1(9),2(7),3,5-tetraene-12-sulfonyl)ethan-1-ol (1447952-43-3)

Guidance literature:

With sodium tetrahydroborate; ethanol; at 0 - 20 ℃; for 4h;

Reference yield:

(1r,4r)-4-(morpholin-4-yl)cyclohexan-1-amine dihydrochloride (412356-24-2,1683576-26-2) → 2-(3-[[4-(morpholin-4-yl)cyclohexyl]amino]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1(9),2(7),3,5-tetraene-12-sulfonyl)ethan-1-ol (1447952-43-3)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate; triethylamine / acetonitrile / 48 h / 80 °C

2: palladium 10% on activated carbon; hydrogen / 48 h / 40 °C

3: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

4: sodium tetrahydroborate; ethanol / 4 h / 0 - 20 °C

With sodium tetrahydroborate; ethanol; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In dichloromethane; acetonitrile;

Reference yield:

C17H15N3O3S (1447956-87-7) → 2-(3-[[4-(morpholin-4-yl)cyclohexyl]amino]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1(9),2(7),3,5-tetraene-12-sulfonyl)ethan-1-ol (1447952-43-3)

Guidance literature:

Multi-step reaction with 5 steps

1: trichlorophosphate / 3 h / 100 °C

2: potassium carbonate; triethylamine / acetonitrile / 48 h / 80 °C

3: palladium 10% on activated carbon; hydrogen / 48 h / 40 °C

4: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

5: sodium tetrahydroborate; ethanol / 4 h / 0 - 20 °C

With sodium tetrahydroborate; ethanol; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; trichlorophosphate; In dichloromethane; acetonitrile;

upstream raw materials:

(1r,4r)-4-(morpholin-4-yl)cyclohexan-1-amine dihydrochloride

C₂₂H₃₁N₅O₅S₂

C₁₉H₂₇N₅OS

C₂₇H₃₃N₅O₃S

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