N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)cyclopropyl)ethyl)-1-(4-methoxybenzyl)-3-methyl-1H-indazol-5-amine

Base Information

Chemical Name:N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)cyclopropyl)ethyl)-1-(4-methoxybenzyl)-3-methyl-1H-indazol-5-amine
CAS No.:1266336-39-3
Molecular Formula:C₃₀H₃₅ClN₆O
Molecular Weight:531.101
Hs Code.:

Synonyms:N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)cyclopropyl)ethyl)-1-(4-methoxybenzyl)-3-methyl-1H-indazol-5-amine

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Chemical Property of N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)cyclopropyl)ethyl)-1-(4-methoxybenzyl)-3-methyl-1H-indazol-5-amine

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Technology Process of N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)cyclopropyl)ethyl)-1-(4-methoxybenzyl)-3-methyl-1H-indazol-5-amine

There total 12 articles about N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)cyclopropyl)ethyl)-1-(4-methoxybenzyl)-3-methyl-1H-indazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1266336-38-2
1-(4-methoxybenzyl)-3-methyl-1H-indazol-5-amine

: 1266335-55-0
2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethyl 4-methylbenzenesulfonate

: 1266336-39-3
N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)cyclopropyl)ethyl)-1-(4-methoxybenzyl)-3-methyl-1H-indazol-5-amine

Guidance literature:: With potassium iodide; In acetonitrile; at 110 ℃; for 1.33333h; Microwave reaction;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1266336-39-3
N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)cyclopropyl)ethyl)-1-(4-methoxybenzyl)-3-methyl-1H-indazol-5-amine

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

2: hydrogen / 10% palladium on activated charcoal / ethyl acetate; methanol / 0.5 h

3: potassium iodide / acetonitrile / 1.33 h / 110 °C / Microwave reaction

With hydrogen; caesium carbonate; potassium iodide; 10% palladium on activated charcoal; In methanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 40621-84-9
3-methyl-5-nitro-1H-indazole

: 1266336-39-3
N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)cyclopropyl)ethyl)-1-(4-methoxybenzyl)-3-methyl-1H-indazol-5-amine

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

2: hydrogen / 10% palladium on activated charcoal / ethyl acetate; methanol / 0.5 h

3: potassium iodide / acetonitrile / 1.33 h / 110 °C / Microwave reaction

With hydrogen; caesium carbonate; potassium iodide; 10% palladium on activated charcoal; In methanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;