5-(benzyloxycarbonyl)-2,7-bis(1,1-dimethylpropyl)-9,9-dimethylxanthene-4-carboxylic acid

Base Information

Chemical Name:5-(benzyloxycarbonyl)-2,7-bis(1,1-dimethylpropyl)-9,9-dimethylxanthene-4-carboxylic acid
CAS No.:130525-53-0
Molecular Formula:C₃₄H₄₀O₅
Molecular Weight:528.689
Hs Code.:

Synonyms:5-(benzyloxycarbonyl)-2,7-bis(1,1-dimethylpropyl)-9,9-dimethylxanthene-4-carboxylic acid

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Chemical Property of 5-(benzyloxycarbonyl)-2,7-bis(1,1-dimethylpropyl)-9,9-dimethylxanthene-4-carboxylic acid

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Technology Process of 5-(benzyloxycarbonyl)-2,7-bis(1,1-dimethylpropyl)-9,9-dimethylxanthene-4-carboxylic acid

There total 7 articles about 5-(benzyloxycarbonyl)-2,7-bis(1,1-dimethylpropyl)-9,9-dimethylxanthene-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 130525-40-5
2,7-bis(1,1-dimethylpropyl)-9,9-dimethylxanthene-4,5-dicarboxylic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 130525-53-0
5-(benzyloxycarbonyl)-2,7-bis(1,1-dimethylpropyl)-9,9-dimethylxanthene-4-carboxylic acid

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1021/ja00180a038

Reference yield:

: 19814-75-6
9,9-dimethylxanthene

: 130525-53-0
5-(benzyloxycarbonyl)-2,7-bis(1,1-dimethylpropyl)-9,9-dimethylxanthene-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: FeCl₃ / CH₂Cl₂ / 1.) from 0 deg C to RT, 3 h, 2.) 20 h

2: bromine / CCl₄ / 1.) from 0 deg C to RT, 4 h, 2.) 8 h

3: bromine, Fe / CCl₄ / 11 h / Ambient temperature

4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) from -78 deg C to 5 deg C

5: 68 percent / 4-(dimethylamino)pyridine, dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 3 h / Ambient temperature

With dmap; n-butyllithium; bromine; iron(III) chloride; iron; dicyclohexyl-carbodiimide; In tetrachloromethane; dichloromethane;
DOI:10.1021/ja00180a038

Reference yield:

: 90-47-1
xanth-9-one

: 130525-53-0
5-(benzyloxycarbonyl)-2,7-bis(1,1-dimethylpropyl)-9,9-dimethylxanthene-4-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / toluene / 1.) from 0 deg C to RT, 3 h, 2.) 14 h

2: FeCl₃ / CH₂Cl₂ / 1.) from 0 deg C to RT, 3 h, 2.) 20 h

3: bromine / CCl₄ / 1.) from 0 deg C to RT, 4 h, 2.) 8 h

4: bromine, Fe / CCl₄ / 11 h / Ambient temperature

5: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) from -78 deg C to 5 deg C

6: 68 percent / 4-(dimethylamino)pyridine, dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 3 h / Ambient temperature

With dmap; n-butyllithium; bromine; iron(III) chloride; iron; dicyclohexyl-carbodiimide; In tetrachloromethane; dichloromethane; toluene;
DOI:10.1021/ja00180a038