(S)-N-(9-phenylfluoren-9-yl)-o-bromophenylalanine

Base Information

• Chemical Name: (S)-N-(9-phenylfluoren-9-yl)-o-bromophenylalanine
• CAS No.: 147912-84-3
• Molecular Formula: C₂₈H₂₂BrNO₂
• Molecular Weight: 484.392
• Mol file: 147912-84-3.mol

Synonyms:(S)-N-(9-phenylfluoren-9-yl)-o-bromophenylalanine

Chemical Property of (S)-N-(9-phenylfluoren-9-yl)-o-bromophenylalanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (S)-N-(9-phenylfluoren-9-yl)-o-bromophenylalanine

There total 1 articles about (S)-N-(9-phenylfluoren-9-yl)-o-bromophenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-amino-3-(2-bromophenyl)propanoic acid (42538-40-9) + 9-bromo-9-phenyl-9H-fluorene (55135-66-5) → (S)-N-(9-phenylfluoren-9-yl)-o-bromophenylalanine (147912-84-3)

Guidance literature:

With chloro-trimethyl-silane; lead(II) nitrate; triethylamine; Yield given. Multistep reaction; 1.) CHCl₃, 2 h, reflux, 2.) CHCl₃, r.t., 4 d;

DOI:10.1021/jo00062a018

Reference yield: 90.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (S)-N-(9-phenylfluoren-9-yl)-o-bromophenylalanine (147912-84-3) → (S)-3-(9-phenylfluoren-9-yl)-4-<(2-bromophenyl)methyl>oxazolidin-5-one (147976-11-2)

Guidance literature:

With toluene-4-sulfonic acid; In tetrahydrofuran; water; Ambient temperature;

DOI:10.1021/jo00062a018

Reference yield:

(S)-N-(9-phenylfluoren-9-yl)-o-bromophenylalanine (147912-84-3) → (S)-2-indan-1-one

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / p-toluenesulfonic acid monohydrate / H₂O; tetrahydrofuran / Ambient temperature

2: 98 percent / 1.) n-BuLi, 2.) AcOH / multistep reaction; other oxazolidinones, enantioselectivity

With n-butyllithium; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; water;

DOI:10.1021/jo00062a018

upstream raw materials:

(S)-2-amino-3-(2-bromophenyl)propanoic acid

9-bromo-9-phenyl-9H-fluorene

Downstream raw materials:

(S)-3-(9-phenylfluoren-9-yl)-4-<(2-bromophenyl)methyl>oxazolidin-5-one

Refernces