(R)-4-bromo-N-(3-bromo-4-(2-(2-methylpyrrolidin-1-yl)ethoxy)phenethyl)thiophene-2-carboxamide

Base Information

Chemical Name:(R)-4-bromo-N-(3-bromo-4-(2-(2-methylpyrrolidin-1-yl)ethoxy)phenethyl)thiophene-2-carboxamide
CAS No.:1199814-71-5
Molecular Formula:C₂₀H₂₄Br₂N₂O₂S
Molecular Weight:516.297
Hs Code.:

Synonyms:(R)-4-bromo-N-(3-bromo-4-(2-(2-methylpyrrolidin-1-yl)ethoxy)phenethyl)thiophene-2-carboxamide

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Chemical Property of (R)-4-bromo-N-(3-bromo-4-(2-(2-methylpyrrolidin-1-yl)ethoxy)phenethyl)thiophene-2-carboxamide

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Technology Process of (R)-4-bromo-N-(3-bromo-4-(2-(2-methylpyrrolidin-1-yl)ethoxy)phenethyl)thiophene-2-carboxamide

There total 6 articles about (R)-4-bromo-N-(3-bromo-4-(2-(2-methylpyrrolidin-1-yl)ethoxy)phenethyl)thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1199814-70-4
C₁₅H₁₃Br₂NO₃S

: 765-38-8,41720-98-3,59335-84-1,79171-53-2
(R)-(-)-2-methylpyrrolidine

: 1199814-71-5
(R)-4-bromo-N-(3-bromo-4-(2-(2-methylpyrrolidin-1-yl)ethoxy)phenethyl)thiophene-2-carboxamide

Guidance literature:: With MP-B(OAc)3H; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2009.04.106

Reference yield:

: 1174651-21-8
4-bromo-N-(3-bromo-4-methoxyphenethyl)thiophene-2-carboxamide

: 1199814-71-5
(R)-4-bromo-N-(3-bromo-4-(2-(2-methylpyrrolidin-1-yl)ethoxy)phenethyl)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron tribromide / dichloromethane / 2.33 h / -78 - 25 °C / 760.05 Torr / Inert atmosphere

1.2: 20 °C / 760.05 Torr / Inert atmosphere

2.1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 1 h / 120 °C / 760.05 Torr / Inert atmosphere; Microwave irradiation

3.1: water; trifluoroacetic acid / 1,2-dichloro-ethane / 1 h / 100 °C / 760.05 Torr / Inert atmosphere; Microwave irradiation

4.1: PS-triacetoxyborohydride / methanol; dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

With water; boron tribromide; caesium carbonate; trifluoroacetic acid; potassium iodide; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1174651-00-3
4-bromo-N-(3-bromo-4-hydroxyphenethyl)thiophene-2-carboxamide

: 1199814-71-5
(R)-4-bromo-N-(3-bromo-4-(2-(2-methylpyrrolidin-1-yl)ethoxy)phenethyl)thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 1 h / 120 °C / 760.05 Torr / Inert atmosphere; Microwave irradiation

2: water; trifluoroacetic acid / 1,2-dichloro-ethane / 1 h / 100 °C / 760.05 Torr / Inert atmosphere; Microwave irradiation

3: PS-triacetoxyborohydride / methanol; dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

With water; caesium carbonate; trifluoroacetic acid; potassium iodide; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;