1-methyl-N-[4-methyl-2-(3-nitrobenzyl)-1,3-thiazol-5-yl]-1H-pyrazole-5-carboxamide

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Chemical Name:1-methyl-N-[4-methyl-2-(3-nitrobenzyl)-1,3-thiazol-5-yl]-1H-pyrazole-5-carboxamide
CAS No.:1318757-06-0
Molecular Formula:C₁₆H₁₅N₅O₃S
Molecular Weight:357.393
Hs Code.:

Synonyms:1-methyl-N-[4-methyl-2-(3-nitrobenzyl)-1,3-thiazol-5-yl]-1H-pyrazole-5-carboxamide

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Chemical Property of 1-methyl-N-[4-methyl-2-(3-nitrobenzyl)-1,3-thiazol-5-yl]-1H-pyrazole-5-carboxamide

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Technology Process of 1-methyl-N-[4-methyl-2-(3-nitrobenzyl)-1,3-thiazol-5-yl]-1H-pyrazole-5-carboxamide

There total 5 articles about 1-methyl-N-[4-methyl-2-(3-nitrobenzyl)-1,3-thiazol-5-yl]-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 16034-46-1
1-methyl-1H-pyrazole-5-carboxylic acid

: 1318758-19-8
tert-butyl [4-methyl-2-(3-nitrobenzyl)-1,3-thiazol-5-yl]carbamate

: 1318757-06-0
1-methyl-N-[4-methyl-2-(3-nitrobenzyl)-1,3-thiazol-5-yl]-1H-pyrazole-5-carboxamide

Guidance literature:: tert-butyl [4-methyl-2-(3-nitrobenzyl)-1,3-thiazol-5-yl]carbamate; With hydrogenchloride; In ethanol; water; at 50 ℃; for 1h;

With sodium hydrogencarbonate; sodium hydroxide; In ethanol; water; at 0 ℃; pH=9 - 10;

1-methyl-1H-pyrazole-5-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl acetamide; at 0 - 60 ℃; for 2h;

Reference yield:

: 621-50-1
(3-nitrophenyl)acetonitrile

: 1318757-06-0
1-methyl-N-[4-methyl-2-(3-nitrobenzyl)-1,3-thiazol-5-yl]-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate / ethyl acetate / 20 °C

2.1: pyridine / ethanol / 48 h / 20 °C

3.1: sodium hydroxide; water / tetrahydrofuran; methanol

3.2: Cooling with ice / Cooling with ice

4.1: triethylamine; diphenyl phosphoryl azide / 2 h / 90 °C

5.1: hydrogenchloride / ethanol; water / 1 h / 50 °C

5.2: 0 °C / pH 9 - 10

5.3: 2 h / 0 - 60 °C

With pyridine; hydrogenchloride; diphenyl phosphoryl azide; water; O,O-Diethyl hydrogen phosphorodithioate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate;

Reference yield:

: 1318758-17-6
ethyl 4-methyl-2-(3-nitrobenzyl)-1,3-thiazole-5-carboxylate

: 1318757-06-0
1-methyl-N-[4-methyl-2-(3-nitrobenzyl)-1,3-thiazol-5-yl]-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / tetrahydrofuran; methanol

1.2: Cooling with ice / Cooling with ice

2.1: triethylamine; diphenyl phosphoryl azide / 2 h / 90 °C

3.1: hydrogenchloride / ethanol; water / 1 h / 50 °C

3.2: 0 °C / pH 9 - 10

3.3: 2 h / 0 - 60 °C

With hydrogenchloride; diphenyl phosphoryl azide; water; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water;