N-(4-[6-(2-ethylhexanamido)indol-1-ylmethyl]benzoyl)benzenesulphonamide

Base Information

Chemical Name:N-(4-[6-(2-ethylhexanamido)indol-1-ylmethyl]benzoyl)benzenesulphonamide
CAS No.:104437-29-8
Molecular Formula:C₃₀H₃₃N₃O₄S
Molecular Weight:531.676
Hs Code.:

Synonyms:N-(4-[6-(2-ethylhexanamido)indol-1-ylmethyl]benzoyl)benzenesulphonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-[6-(2-ethylhexanamido)indol-1-ylmethyl]benzoyl)benzenesulphonamide

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Technology Process of N-(4-[6-(2-ethylhexanamido)indol-1-ylmethyl]benzoyl)benzenesulphonamide

There total 7 articles about N-(4-[6-(2-ethylhexanamido)indol-1-ylmethyl]benzoyl)benzenesulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 104437-29-8
N-(4-[6-(2-ethylhexanamido)indol-1-ylmethyl]benzoyl)benzenesulphonamide

Guidance literature:

Reference yield:

: 5318-27-4
6-amino-1H-indole

: 104437-29-8
N-(4-[6-(2-ethylhexanamido)indol-1-ylmethyl]benzoyl)benzenesulphonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 56 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: 1.) a) NaH / 1.) a) DMF, 0 deg C, 15 min, b) RT, 30 min, 2.) a) 0 deg C, 15 min, b) RT, 4.25 h

3: 46 percent / H₂O, LiOH / methanol; tetrahydrofuran / 16 h

4: Et₃N / methanol

5: 1.) NaH / 1.) DMF, 1 h, 2.) 1 h

With lithium hydroxide; water; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00171a018

Reference yield:

: 4769-96-4
6-nitroindole

: 104437-29-8
N-(4-[6-(2-ethylhexanamido)indol-1-ylmethyl]benzoyl)benzenesulphonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 2587.7 Torr

2: 56 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: 1.) a) NaH / 1.) a) DMF, 0 deg C, 15 min, b) RT, 30 min, 2.) a) 0 deg C, 15 min, b) RT, 4.25 h

4: 46 percent / H₂O, LiOH / methanol; tetrahydrofuran / 16 h

5: Et₃N / methanol

6: 1.) NaH / 1.) DMF, 1 h, 2.) 1 h

With lithium hydroxide; water; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00171a018